Evidence map›Paper›PMID 40810409›Full record

ArticleActa odontologica Scandinavica2025

An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults.

Natalia Petrenya, Laila A Hopstock, Elin Hadler-Olsen, Farah Asa'ad, Lena Larsson, Svetlana N Zykova, Gro Eirin Holde, Alexandre R Vieira, Birgitta Jönsson

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Article in Acta odontologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Natalia PetrenyaThe Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway. natalia.petrenya%40tromsfylke.no.
Laila A HopstockDepartment of Health and Care Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Elin Hadler-OlsenThe Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway; Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Farah Asa'adDepartment of Oral Biochemistry, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lena LarssonDepartment of Oral Biochemistry, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Svetlana N ZykovaThe Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway; Center for Research and Education, University Hospital of North Norway, Tromsø, Norway; Hormone Laboratory, Department of Medical Biochemistry, Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Oslo, Norway.
Gro Eirin HoldeThe Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway; Department of Clinical Dentistry, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Alexandre R VieiraSchool of Dental Medicine, East Carolina University, Greenville, NC, USA.
Birgitta JönssonThe Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway; Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective ANRIL is a pleiotropic gene with a strong link to periodontitis. ANRIL gene variant rs1537373 is associated with altered CDKN2B gene expression, which is linked to obesity. In this explorative, cross-sectional population-based study, we aimed to investigate the hypothesis that ANRIL (rs1537373) T>G may be associated with periodontitis through interactions, focusing on rs1537373×obesity interaction. Methods Genotyping for ANRIL (rs1537373), and clinical and periodontal examination were performed in 3554 participants (aged 40-93 years, 52% women) from the seventh survey of the Tromsø Study (2015-2016), Norway. We defined periodontitis stage based on radiographic bone loss (2018 AAP/EFP classification). Results The individual association between rs1537373 and periodontitis, as well as multiplicative and additive interactions between rs1537373 and age, sex, smoking, and obesity on periodontitis under a recessive model were studied. We found multiplicative and additive interactions between rs1537373 and obesity. When compared with GT/TT genotype and no obesity, GG genotype and obesity was associated with higher odds for periodontitis stage III-IV (OR=2.47, 95%CI=1.48-4.12, p=0.001; relative excess risk due to interaction=1.51, 95%CI=0.26-2.77, p=0.018; attributable proportion due to interaction=0.61; 95%CI=0.35-0.87, p<0.001). Conclusion Our findings suggest that rs1537373 GG genotype and obesity were jointly associated with periodontitis stage III-IV in this Norwegian population.

Indexed as

ObesityPeriodontitisRNA, Long NoncodingAdultAgedAged, 80 and overCross-Sectional StudiesFemaleGenotypeHumansMaleMiddle AgedNorwayPolymorphism, Single NucleotideCDKN2B antisense RNA, humanRNA, Long Noncoding

Identifiers

PMID40810409
PMCPMC12372528

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