Evidence map›Paper›PMID 40810762›Full record

ArticlePharmacological reports : PR2025

Genetic variants in GRIN2B and NTRK2 on the etiology and treatment response to valproate and lithium in patients with bipolar disorder.

Beatriz Camarena, Marco Antonio Sanabrais-Jiménez, Carlo Esteban Sotelo-Ramírez, Joanna Jiménez-Pavón, Pamela Morales-Cedillo, Hiram Ortega-Ortíz, Claudia Becerra-Palars

Abstract read
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In one paragraph

Article in Pharmacological reports : PR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Beatriz CamarenaPharmacogenetics Department, Subdirectorate of Clinical Research, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101. Col. San Lorenzo, Huipulco. CP 14370, Mexico City, Mexico. bcamarenam@gmail.com.ORCID http://orcid.org/0000-0001-7737-501X
Marco Antonio Sanabrais-JiménezPharmacogenetics Department, Subdirectorate of Clinical Research, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101. Col. San Lorenzo, Huipulco. CP 14370, Mexico City, Mexico.ORCID http://orcid.org/0000-0002-7722-5940
Carlo Esteban Sotelo-RamírezPharmacogenetics Department, Subdirectorate of Clinical Research, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101. Col. San Lorenzo, Huipulco. CP 14370, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-9924-1434
Joanna Jiménez-PavónAffective Disorders Clinic, Clinical Services Directorate, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico.ORCID http://orcid.org/0000-0002-3654-9922
Pamela Morales-CedilloPharmacogenetics Department, Subdirectorate of Clinical Research, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101. Col. San Lorenzo, Huipulco. CP 14370, Mexico City, Mexico.ORCID http://orcid.org/0000-0003-3142-807X
Hiram Ortega-OrtízClinical Services Directorate, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico.ORCID http://orcid.org/0000-0002-0462-2996
Claudia Becerra-PalarsClinical Services Directorate, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-5191-7685

Funding

Cátedras CONACyT 1683CONACyT-FOSISS 261459
6 · The paper itself

Abstract

backgroundThe pharmacological maintenance treatment for bipolar disorder patients depends on mood stabilizers such as lithium and valproate. An association between GRIN2B and NTRK2 gene polymorphisms and treatment response to lithium and valproate has been reported. Therefore, we examined the relationship between polymorphisms of GRIN2B and NTRK2 and the long-term treatment response to valproate and lithium in bipolar disorder patients.

methodsWe performed a genetic association study involving bipolar disorder patients treated with valproate and lithium, along with a control group. The long-term treatment response was retrospectively assessed using Alda's scale. Genotyping of GRIN2B (rs1806201, rs890) and NTRK2 (rs2289656) was conducted with allele discrimination TaqMan assays.

resultsWe analyzed 251 bipolar disorder patients, 130 treated with valproate and 121 with lithium, and 300 controls. The analysis, which controlled for sex and age as covariates, observed an association between rs1806201 and BD (p = 0.003). The analysis of treatment response showed an effect of the NTRK2/rs2289656 and treatment response to valproate, with the number of depressive, hypomanic, psychotic, and mixed episodes as covariates (p = 0.043). No association was found between the two genes analyzed and the response to lithium treatment.

conclusionsOur findings suggest that GRIN2B and NTRK2 may play a crucial role in the cause of bipolar disorder. The analysis of treatment response revealed a link between the NTRK2 gene and valproate response in BD patients. However, our results did not reproduce the association of these two genes with lithium response in Mexican patients.

Indexed as

Antimanic AgentsBipolar DisorderMembrane GlycoproteinsReceptors, N-Methyl-D-AspartateReceptor, trkBValproic AcidAdultFemaleGenetic Association StudiesGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideRetrospective StudiesTreatment OutcomeAntimanic AgentsMembrane GlycoproteinsNR2B NMDA receptorReceptors, N-Methyl-D-AspartateReceptor, trkBtropomyosin-related kinase-B, humanValproic AcidBipolar disorderMood stabilizersPharmacogeneticsTreatment response

Identifiers

PMID40810762

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.