Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025
Radiation-induced maculopathy and fluocinolone acetonide implant.
Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinical Classification of Radiation Maculopathy as a Predictor of Functional Response to Intravitreal Dexamethasone Implant.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study evaluates the effectiveness of fluocinolone acetonide (FAc) implants in managing radiation maculopathy, a complication of ocular irradiation. The primary outcomes were the change in best-corrected visual acuity (BCVA) and central foveal thickness (CFT), and the impact on therapeutic burden and intraocular pressure (IOP).
methodsThis was a retrospective, multicenter, observational study conducted across three French oncology-ophthalmology reference centers. Twelve eyes of twelve patients with radiation maculopathy following ocular irradiation for uveal melanoma were included. All patients received at least one injection of the FAc implant between February 2021 and July 2023. Data on tumor characteristics, lens status, BCVA, CFT, IOP, and SD-OCT findings were collected. The number and types of intravitreal injections before and after FAc implantation were analyzed.
resultsMedian final BCVA improved significantly to 72.5 ETDRS letters (IQR 57.5-76.2) (Snellen equivalent: 20/32) (p = 0.03). Median final CFT decreased significantly to 328.0 μm (IQR 286.0-405.0) (p = 0.04). The therapeutic burden was significantly reduced, with the mean injection interval increasing from 4.2 to 6.5 months (p = 0.03) and the annual number of injections decreasing from 3.2 to 0.2 (p < 0.001). IOP significantly increased during follow-up, peaking at 21.5 mmHg (IQR 18-25) (p < 0.001) but returned to the baseline of 13 mmHg after the treatment adjustments made at the final visit (IQR 11.5-17.2) (p = 0.20).
conclusionFAc implant improved BCVA and significantly reduced the therapeutic burden in patients with radiation maculopathy. However, careful IOP monitoring is required to effectively manage intraocular hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.