ArticleJournal of the National Cancer Institute2025
Financial difficulty among patients with cancer participating in clinical trials and its association with patient survival and quality of life.
Article in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Access to cancer clinical trials in Europe: when trial availability does not match patient need.ESMO open · 2026Article
- Sociodemographic Factors related to Financial Toxicity among Cancer Patients and Survivors:"The Second Cancer Patient Experience Survey" - A Nationwide Study in Japan.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Financial hardship and pain among cancer survivors: a French nationwide cross-sectional analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- The effect of acceptance commitment therapy on the mental health of elderly breast cancer patients.World journal of surgical oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe incidence and worsening of financial difficulty among patients with cancer participating in clinical trials and their relationship with mortality, quality of life, and toxicity outcomes have been understudied. The objective of this study was to understand the incidence of financial difficulty among Canadian patients participating in systemic therapy trials at baseline and after trial participation and to assess the relationship between financial difficulty and clinical outcomes.
methodsThis retrospective cohort study included patients participating in 14 systemic therapy trials conducted by the Canadian Cancer Trials Group for adult patients with advanced cancer. Incidence of financial toxicity at baseline and after trial participation were measured using the European Organisation for Research and Treatment of Cancer QLQ Core Questionnaire. The association of financial difficulty with trial characteristics and patient outcomes (mortality, quality of life, and toxicity) was studied.
resultsOverall, 2766 patients from 14 trials were included, of whom 37% had financial difficulty at baseline and 25% experienced worsening of financial difficulty after trial enrollment compared with their baseline status. Baseline financial difficulty but not the worsening of financial difficulty was associated with worse mortality outcomes. Worsening of financial difficulty was, however, associated with poor global quality of life outcomes and increased odds of clinical toxicities.
conclusionsEven in the setting of a public health system in Canada, one-third of patients experience financial difficulty, with one-quarter of them experiencing worsening of financial difficulty with trial participation, and both were related to worse patient outcomes. Targeted policy-level interventions are needed to understand and address the cause of financial difficulty in patients with cancer.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.