Evidence map›Paper›PMID 40811684›Full record

ReviewJournal of biomaterials applications2026

Advances in the management of ocular anterior segment diseases using biomaterials-based drug delivery systems.

Nayana E Subhash, Meghana Prabhu, Manali Hazarika, Shailaja S, Sulatha V Bhandary, Bharath Raja Guru

Abstract readReview
In one paragraph

Review in Journal of biomaterials applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nayana E SubhashDepartment of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.ORCID 0009-0002-3673-9926
Meghana PrabhuDepartment of Ophthalmology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.ORCID 0009-0002-1920-7549
Manali HazarikaDepartment of Ophthalmology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.
Shailaja SDepartment of Ophthalmology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.ORCID 0000-0002-8273-3755
Sulatha V BhandaryDepartment of Ophthalmology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.ORCID 0000-0002-3150-707X
Bharath Raja GuruDepartment of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.ORCID 0000-0003-2542-7740

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The eye is an essential sense organ and drug delivery to the eye is a challenging task due to protective barriers that hinder drug penetration. Over 90 percent of treatments for eye diseases are topical, but frequent administration over extended periods can lead to toxicity and compliance issues. Over the years, extensive research has been aimed at developing drug delivery systems that enhance drug bioavailability at the target site while minimizing side effects. Innovative drug carrier systems have been researched and developed to extend retention time, decrease administration frequency, improve therapeutic efficacy, and ensure biocompatibility. In this article, we delve into the various ocular barriers affecting drug delivery and provide an overview of the utilization of biomaterials and nanotechnology in ocular drug delivery. We explore its applications in the treatment and management of various diseases affecting the anterior segment of the eye.

Indexed as

Anterior Eye SegmentBiocompatible MaterialsDrug CarriersDrug Delivery SystemsEye DiseasesAnimalsHumansBiocompatible MaterialsDrug Carriersanterior segment of eyebiomaterialsnanotechnologyocular drug deliverypolymers in ocular delivery

Identifiers

PMID40811684
PMCPMC12638462

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.