Evidence map›Paper›PMID 40811822›Full record

ArticleAmerican journal of physiology. Renal physiology2025

Impaired vascular function in patients with chronic kidney disease who have elevated symmetric dimethylarginine but not asymmetric dimethylarginine.

Ann-Katrin Grotle, Jasdeep Kaur, Rachel J Skow, Taha Ali Alhalimi, Benjamin E Young, Damsara Nandadeva, Brandi Y Stephens, Ponnaiah Mohan, Paul J Fadel

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ann-Katrin GrotleDepartment of Sports, Food and Natural Sciences, Western Norway University of Applied Sciences, Bergen, Norway.ORCID 0000-0003-2990-8744
Jasdeep KaurDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, United States.ORCID 0000-0002-1264-6103
Rachel J SkowFaculty of Nursing, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-0163-9792
Taha Ali AlhalimiDepartment of Kinesiology, The University of Texas at Arlington, Arlington, Texas, United States.ORCID 0000-0002-4939-4149
Benjamin E YoungDepartment of Kinesiology, Health Promotion and Recreation, University of North Texas, Denton, Texas, United States.ORCID 0000-0003-0239-005X
Damsara NandadevaDepartment of Physiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.ORCID 0000-0002-9635-1117
Brandi Y StephensDepartment of Kinesiology, The University of Texas at Arlington, Arlington, Texas, United States.
Ponnaiah MohanRenal Specialists of North Texas, Arlington, Texas, United States.
Paul J FadelDepartment of Kinesiology, The University of Texas at Arlington, Arlington, Texas, United States.ORCID 0000-0002-0115-0743

Funding

HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01 HL-127071NHLBI NIH HHS R01 HL127071
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is associated with heightened cardiovascular disease (CVD) risk, partly due to impaired peripheral vascular function. Symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) are emerging biomarkers implicated in nitric oxide (NO) regulation and vascular health. Although ADMA is a well-established inhibitor of NO synthesis, recent evidence suggests that SDMA may also play a critical role in vascular health, especially in CKD before end-stage. Thus, in 23 stages 3 and 4 patients with CKD (66 ± 9 yr) and 32 age-matched controls (64 ± 8 yr), we compared serum SDMA and ADMA levels and examined their associations with vascular function, including flow-mediated dilation (FMD), peak blood velocity to reactive hyperemia, and carotid-femoral pulse wave velocity (cfPWV). SDMA was significantly elevated in patients with CKD (163 ± 37 vs. 100 ± 15 ng/mL,

Indexed as

ArginineKidneyRenal CirculationRenal Insufficiency, ChronicVascular DiseasesAgedBiomarkersBlood Flow VelocityCase-Control StudiesFemaleGlomerular Filtration RateHumansHyperemiaMaleMiddle AgedPredictive Value of TestsArginineBiomarkersdimethylargininesymmetric dimethylargininearterial stiffnesscardiovascular diseaseendothelial functionflow-mediated dilationuremic toxins

Identifiers

PMID40811822
PMCPMC12440317

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.