ArticleThe Journal of allergy and clinical immunology2025
Prostaglandin I
Article in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
14 authors.
Funding
Abstract
backgroundT regulatory (Treg) cells dampen immune activation. Treg cells downregulate the type 2 response to innocuous environmental antigens that produce allergic airway inflammation; however, ST2-positive Treg cells promote allergic airway inflammation. Prostaglandin I
objectiveWe sought to define the mechanisms responsible for PGI
methodsTreg cell-specific IP-deficient mice, Treg cell fate-tracking IP-deficient mice, and Treg cell-specific IP- and β-catenin-deficient mice were exposed to an Alternaria alternata extract sensitization and challenge model. Bronchoalveolar lavage fluid was evaluated for cell number, cell differential, and cytokines by ELISA. Lungs were evaluated by flow cytometry and histopathology.
resultsUtilizing Treg cell-specific IP-deficient mice, we found that loss of PGI
conclusionsTogether, these data further support the importance of PGI
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Registered trials
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