Evidence map›Paper›PMID 40812706›Full record

ArticleEnvironmental research2025

Associations between persistent organic pollutants and thyroid-related hormones and homeostasis parameters in middle-aged to older men and postmenopausal women: The HCHS/SOL.

Chibuzor Abasilim, Victoria Persky, Robert M Sargis, Tessa Day, Konstantina Tsintsifas, Martha Daviglus, Jianwen Cai, Sally Freels, Arielle Grieco, Brandilyn A Peters and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chibuzor AbasilimJoseph J. Zilber College of Public Health, University of Wisconsin-Milwaukee, WI, USA; Division of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois Chicago, IL, USA; Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, IL, USA. Electronic address: cabasi2@uic.edu.
Victoria PerskyDivision of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, IL, USA.
Robert M SargisDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago and Medical Service, Jesse Brown VA Medical Center, IL, USA.
Tessa DayDivision of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, IL, USA.
Konstantina TsintsifasDivision of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, IL, USA.
Martha DaviglusInstitute for Minority Health Research, University of Illinois Chicago, IL, USA.
Jianwen CaiDepartment of Biostatistics, University of North Carolina at Chapel Hill, NC, USA.
Sally FreelsDivision of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, IL, USA.
Arielle GriecoDivision of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, IL, USA.
Brandilyn A PetersDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, USA.
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, USA.
Gregory A TalaveraDepartment of Psychology, San Diego State University, CA, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, MN, USA.
Mark DavisDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Richard JonesDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Andreas SjodinDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Mary E TurykDivision of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, IL, USA.

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Persistent Organic Pollutants, Endogenous Hormones and Diabetes in LatinosR01ES025159 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PERSKY, VICTORIA W · 2016 to 2019
$2.5M
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NHGRI NIH HHS HHSN268201300003CNHLBI NIH HHS HHSN268201300001CNHLBI NIH HHS HHSN268201300003INHLBI NIH HHS HHSN268201300004CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIDDK NIH HHS P30 DK111022NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES025159NIOSH CDC HHS T42 OH008672
6 · The paper itself

Abstract

backgroundPrevious research has yielded inconsistent results on associations of persistent organic pollutants (POPs) with thyroid hormones, which has been implicated in diabetes development. Studies specifically investigating associations with hypothalamic-pituitary-thyroid (HPT) homeostasis parameters or associations in postmenopausal women are limited.

methodsUsing baseline examination data between 2008 and 2011, we studied 1073 men and 716 postmenopausal women participating in an ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Survey-weighted multivariable linear regression models examined associations of serum concentrations of eight organochlorine pesticides (OCPs), twenty-four polychlorinated biphenyls (PCBs), ten polybrominated diphenyl ethers and polybrominated biphenyl (PBB) 153 with thyroid stimulating hormone (TSH), triiodothyronine (T3), free thyroxine (FT4), and thyroid homeostasis parameters. Homeostasis parameters included T3-to-FT4 and TSH-to-T3 ratios, thyroid feedback quantile-based index, TSH index, and parametric thyroid feedback quantile-based index. POPs were analyzed in quartiles, except for mirex and 1,1,1-trichloro-2,2-diphenylethane (p,p'-DDT) which were categorized as non-detected (reference), ≤ median, and > median of detected values.

resultsp,p'-DDT was positively associated with T3 and PBB-153 negatively associated with FT4 in postmenopausal women and men. In postmenopausal women only, PBB-153 was positively associated with the T3-to-FT4 ratio (β = 3.34; 95 %CI:0.53,6.14) suggesting increased deiodination or peripheral thyroid hormone sensitivity and negatively associated with PTFQI and TFQI indicating greater central sensitivity to FT4. In men only, PCBs and select OCPs were operative in the disruption of thyroid hormones and homeostasis parameters. For instance, a one quartile increase in ∑24-PCBs was positively associated with TSHI (β = 0.06; 95 %CI:0.001,0.12) and relative increases in the geometric mean of TSH (β = 7.25mIU/L, 95 %CI:1.01,12.8), and the TSH-to-T3 ratio (β = 8.33, 95 %CI:2.02,13.9). Associations between POPs and thyroid homeostasis parameters were negative in men with adiposity measures at or above the median, but positive when adiposity measures were below the median. In postmenopausal women, associations by adiposity measures were opposite to those observed in men.

conclusionWe report associations of select POPs with disruptions in thyroid hormones as well as measures of central and peripheral thyroid hormone sensitivity. Given the persistence of these chemicals in humans and the environment, understanding their effects on thyroid homeostasis pathways may be critical for diabetes prevention.

Indexed as

Persistent Organic PollutantsThyroid HormonesAdiposityFemaleHispanic or LatinoHomeostasisHumansMaleMiddle AgedPersistent Organic PollutantsThyroid HormonesAdiposityFree T4Persistent organic pollutantsT3Thyroid homeostasisTSH

Identifiers

PMID40812706
PMCPMC12588783

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.