Evidence map›Paper›PMID 40812784›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2025

Long-term adiposity in early adulthood affects coronary artery calcification incidence in midlife: a 25-year longitudinal study.

Shunyi Li, Haobin Zhou, Wenyan Li, Liusheng Wang, Qiming Zhao, Jun Chen, Lin Song, Shichao Li, Sijie Jiang, Weijing Feng and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shunyi LiState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Haobin ZhouDepartment of Cardiology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
Wenyan LiState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Liusheng WangState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Qiming ZhaoState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Jun ChenState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Lin SongState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Shichao LiState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Sijie JiangState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Weijing FengState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Qianqin LiNanfang Hospital Baiyun Branch, Southern Medical University, Guangzhou, Guangdong 510405, China.
Dingli XuState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0002-3193-4354
Qingchun ZengState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0001-7665-8237

Funding

CARDIAGuangdong Basic and Applied Basic Research Foundation 2024A1515011387Guangzhou Science and Technology Plan 2023B01J1011Guangzhou Science and Technology Plan 2023B03J1243National Natural Science Foundation of China 82270374NHLBINHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007IPresident Foundation of Nanfang HospitalSouthern Medical University BYYZ24009
6 · The paper itself

Abstract

aimsThe study aimed to evaluate longitudinal adiposity exposure, assessed by body roundness index (BRI), from young adulthood and its association with the risk of coronary artery calcification (CAC) incidence in mid-life. METHODS AND

resultsWe included 2102 participants from the CARDIA study with available BRI measurements at eight follow-up visits over 25 years. Cardiac computed tomography at the year 25 exam was used to assess the presence of CAC (CAC > 0). The cumulative BRI (cBRI) was calculated as the mean of the BRI between consecutive visits multiplied by the number of years. Logistic regression models and restricted cubic spline (RCS) analyses were used to assess the relationship between cBRI and the risk of CAC incidence. A total of 598 participants developed CAC over the 25-year follow-up period. Higher cBRI was associated with an increased risk of CAC incidence. Participants were divided into four quartiles based on cBRI. In model 3, the odds ratio (OR) for CAC was 2.52(95%CI, 1.82-3.49) in the top quartile of cBRI. RCS analyses suggested a linear relationship between cBRI and the risk of CAC incidence. Furthermore, multivariable Cox regression showed that individuals in the higher cBRI had a higher risk of all-cause mortality (1.009; 95% CI, 1.003-1.016).

conclusionGreater cBRI from early adulthood was associated with an elevated risk of CAC incidence in mid-life. These findings uncover potential evidence to support that BRI may be a useful marker for identifying individuals at high risk of CAC.

Indexed as

AdiposityCoronary Artery DiseaseVascular CalcificationAdultFemaleFollow-Up StudiesHumansIncidenceLongitudinal StudiesMaleMiddle AgedRisk AssessmentRisk FactorsTomography, X-Ray ComputedUnited Statescardiovascular diseasecomputed tomographycoronary artery calcificationobesity

Identifiers

PMID40812784
PMCPMC12571503

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.