ArticleBMJ open2025
Effects of injecting micro-fragmented adipose tissue (MFAT) in the tendon-bone junction region during anterior cruciate ligament reconstruction on postoperative tendon-bone healing: a protocol for a randomised controlled trial in China.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Microfragmented Adipose Tissue in Pain Management: Bridging Regenerative Biology and Clinical Therapeutics.Pain and therapy · 2026Review
- Micro-Fragmented Adipose Tissue (MFAT) in Orthopedic Regenerative Medicine: A Narrative Review of the Biological Basis and Clinical Evidence.International journal of molecular sciences · 2026Review
- [Research progress of infrapatellar fat pad derived mesenchymal stem cells in treatment of osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAnterior cruciate ligament (ACL) injuries are among the most common sports-related injuries, often requiring surgical reconstruction to restore joint stability and function. However, inflammation and graft-to-bone healing remain critical challenges in postoperative recovery. Micro-fragmented adipose tissue (MFAT), rich in mesenchymal stem cells and anti-inflammatory factors, has shown potential in promoting tissue repair and reducing inflammation. This randomised controlled trial aims to evaluate the efficacy of MFAT injection in enhancing graft-to-bone healing at both the tibial and femoral sides and alleviating postoperative inflammation in ACL reconstruction. METHODS AND ANALYSIS: This is a prospective randomised controlled trial involving 70 patients with acute ACL injuries. Participants will be randomised into two groups: a standard ACL reconstruction group and an ACL reconstruction plus MFAT injection group. In the latter group, MFAT will be prepared from the infrapatellar fat pad and injected intra-articularly during surgery. All patients will follow a standardised postoperative rehabilitation protocol. Data will be collected at baseline and 3, 6 and 12 months postoperatively. Primary outcomes include graft maturity, assessed by signal-to-noise quotient on MRI at 6 and 12 months. Secondary outcomes include visual analogue scale scores, International Knee Documentation Committee scores and inflammatory marker levels (interleukin-6 and tumour necrosis factor-alpha). Additionally, complications such as infection and graft failure will be monitored during follow-up visits. ETHICS AND DISSEMINATION: This study has received ethical approval from the Ethics Committee of Weifang People's Hospital (approval number: KYLL20250105-5). Written informed consent will be obtained from all participants before enrolment. The findings will be published in peer-reviewed journals and presented at relevant conferences to contribute to evidence-based advancements in ACL reconstruction techniques. TRIAL REGISTRATION NUMBER: ChiCTR2500101018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.