Evidence map›Paper›PMID 40813541›Full record

ReviewApoptosis : an international journal on programmed cell death2025

Emerging role of RNA m6A modifications in laryngeal squamous cell carcinoma: insights into tumorigenesis and therapeutic potential.

Guotong Zheng, Jing Bi, Yangyan Yan, Bo Yu, Yong Fu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Apoptosis : an international journal on programmed cell death, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guotong ZhengDepartment of Otorhinolaryngology, Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, Zhejiang, China.
Jing BiDepartment of Otorhinolaryngology, Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, Zhejiang, China.
Yangyan YanDepartment of Otorhinolaryngology, Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, Zhejiang, China.
Bo YuDepartment of Otorhinolaryngology, Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, Zhejiang, China.
Yong FuDepartment of Otorhinolaryngology, Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, Zhejiang, China. 1307022@zju.edu.cn.

Funding

Zhejiang Natural Science Foundation MS25H130006
6 · The paper itself

Abstract

Laryngeal squamous cell carcinoma (LSCC) is one of the major malignant cancers worldwide. Emerging evidence has demonstrated that N6-methyladenosine (m6A) modification affects gene expression by regulating RNA metabolic processes, dynamically and reversibly regulated by its "writers", "erasers" and "readers". m6A modification plays an important role in the occurrence and development of various tumors. Recent studies have shown that m6A modifications are abnormally expressed in LSCC cells and tissues and participate in the malignant phenotypes of LSCC including cell proliferation, invasion, metastasis and chemotherapy resistance by mediating m6A regulators. This fundings may provide new directions for the molecular classification and targeted treatment of LSCC. In this review, we will focus on the molecular mechanism and potential clinical function of m6A modification in LSCC and emphasize its potential as a biomarker for the clinical diagnosis, prognosis, and treatment of LSCC.

Indexed as

AdenosineBiomarkers, TumorCarcinogenesisHead and Neck NeoplasmsLaryngeal NeoplasmsRNA MethylationSquamous Cell Carcinoma of Head and NeckHumansPrognosisAdenosineBiomarkers, TumorN-methyladenosineCancer therapyLaryngeal squamous cell carcinomam6A modificationm6A regulatorsTumorigenesis

Identifiers

PMID40813541

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.