ArticleScientific reports2025
Exploring the role of intrinsic and extrinsic factors on the associations between sarcopenia and falls in older adults.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Prefrontal Cortical Asymmetry and Motor Slowing in Older Women: EEG Evidence That Fear of Falling Modulates Emotional Valence and Reaction Time.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Personality Traits and Their Association With Falls and Fall-Related Psychological Concerns in Adults Aged 50 and Older: A Scoping Review.Health science reports · 2026Review
- Sarcopenia and fall-related outcomes in Chinese adults aged 45 years or older: a longitudinal cohort study.Scientific reports · 2026Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the moderating effects of intrinsic and extrinsic factors on the association between sarcopenia and falls in older adults. This prospective cohort study was conducted among octogenarians residing in the mountainous Sirente geographic area of Central Italy. Sarcopenia was defined by the coexistence of low muscle mass and dynapenia. Data on fall history and incident falls were collected over a two-year period. A general linear model was used to assess whether intrinsic factors (i.e., multimorbidity, polypharmacy, cognitive function, vision status, nutritional status) and extrinsic factors (i.e., social functioning, environmental characteristics) moderated the relationship between sarcopenia (independent variable) and falls (dependent variable). Data of 364 individuals were examined. Fifty participants (13.7%) reported at least one fall event in the 90 days prior to data collection, while 36 participants (10%) reported having fallen during the follow-up period. Results revealed that intrinsic factors, but not extrinsic ones, significantly influenced this association. Specifically, multimorbidity and polypharmacy were associated with both fall history and incidence, while cognitive function and nutritional status emerged as significant moderators in the longitudinal analysis. In conclusion, these findings underscore the importance of addressing specific intrinsic health-related factors in order to more effectively mitigate the risk of falls among older adults with sarcopenia.
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Registered trials
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