Evidence map›Paper›PMID 40813898›Full record

ArticleCommunications biology2025

Unveiling causal relationship between white matter tracts and psychiatric disorders.

Yifan Yu, Tianye Jia, Xiao Lin, Yanping Bao, Suhua Chang, Jie Sun, Teng Gao, Jie Shi, Sizhi Ai, Kai Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yifan YuPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No.2018RU006), Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-7455-6525
Tianye JiaInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-5399-2953
Xiao LinPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No.2018RU006), Peking University, Beijing, China.
Yanping BaoNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-1881-0939
Suhua ChangPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No.2018RU006), Peking University, Beijing, China.
Jie SunCenter for Pain Medicine, Peking University Third Hospital, Beijing, China.
Teng GaoPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No.2018RU006), Peking University, Beijing, China.
Jie ShiNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China.ORCID http://orcid.org/0000-0001-6567-8160
Sizhi AiCenter for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. 2022760748@gzhmu.edu.cn.ORCID http://orcid.org/0000-0001-5701-1235
Kai YuanPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No.2018RU006), Peking University, Beijing, China. yuankai@pku.edu.cn.ORCID http://orcid.org/0000-0002-3498-8163

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

White matter tracts (WMTs), which mediate information transmission in the brain, are closely associated with the pathogenesis of psychiatric disorders, yet the causality of their associations remain unclear. Thus, we employed two-sample bidirectional Mendelian randomization to explore the causality between WMTs and 10 psychiatric disorders. We found that one standard deviation changes of WMTs metrics modified risks for 8 psychiatric disorders by 2·2% to 71·4%. For example, increased fornix/stria terminalis radial diffusivities elevated PTSD risk by 8.3%, while heightened mode anisotropy reduced Tourette syndrome risk by 71.4%. Reversely, alcohol use disorder increased the risk of WMTs abnormalities. Our study provides novel insights into the potential causality between WMTs and psychiatric disorders, indicating that alterations of WMTs may serve as biomarkers for psychiatric disorders.

Indexed as

Mental DisordersWhite MatterDiffusion Tensor ImagingFemaleHumansMaleMendelian Randomization Analysis

Identifiers

PMID40813898
PMCPMC12354733

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.