Evidence map›Paper›PMID 40815348›Full record

ReviewCurrent HIV/AIDS reports2025

Long-Acting Injectable Antiretroviral Drugs for Pregnant and Breastfeeding Women: Current Advances, Challenges, and Future Directions.

Friday Saidi, Mina C Hosseinipour, Benjamin H Chi

Abstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Friday SaidiUNC Project-Malawi, P. Bag A-104, Lilongwe, Malawi. fsaidi@email.unc.edu.ORCID http://orcid.org/0000-0003-1190-1499
Mina C HosseinipourUNC Project-Malawi, P. Bag A-104, Lilongwe, Malawi.
Benjamin H ChiSchool of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Project 3 - Point-of-care Active Case finding & Management (PAC-Man) Model [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]P01HD112215 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael Emmanuel Herce · 2023 to 2026
$6.2M
Mentoring new investigators in PMTCT implementation researchK24AI120796 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Benjamin H. Chi · 2016 to 2026
$1.3M
NIAID NIH HHS K24 AI120796NICHD NIH HHS P01 HD112215
6 · The paper itself

Abstract

purpose of reviewThis review explores the promise and challenges of integrating long-acting antiretroviral agents-cabotegravir, lenacapavir, and cabotegravir-rilpivirine-into HIV prevention and treatment programs for pregnant and breastfeeding populations. It aims to examine current evidence, implementation experiences, and barriers to equitable access. RECENT

findingsEmerging data support the efficacy and safety of long-acting agents during pregnancy and breastfeeding. Recent clinical trials have begun to include pregnant women by design, and national demonstration projects have successfully introduced injectable PrEP in maternal health settings. These developments signal growing recognition of the need for inclusive research and service delivery models. Long-acting antiretrovirals have the potential to transform maternal HIV prevention and treatment. However, challenges such as delayed inclusion in trials, policy constraints, limited product choice, high costs, and funding limitations persist. Addressing these gaps is critical to ensuring equitable access and informing future research and implementation strategies.

Indexed as

Anti-HIV AgentsBreast FeedingHIV InfectionsPregnancy Complications, InfectiousAnimalsDelayed-Action PreparationsFemaleHumansInfectious Disease Transmission, VerticalInjectionsPregnancyAnti-HIV AgentsDelayed-Action PreparationsBreastfeedingHIV preventionHIV treatmentLong acting antiretroviral drugsPregnancy

Identifiers

PMID40815348
PMCPMC12356711

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.