Evidence map›Paper›PMID 40815415›Full record

ReviewCurrent atherosclerosis reports2025

Spontaneous Coronary Artery Dissection (SCAD): Unveiling the Enigma of the Unexpected Coronary Event.

Cristiane C Singulane, Shuo Wang, Kelsey Watts, Macy E Stahl, LeAnn Denlinger, Rachel Lloyd, Pranavi Pallinti, Lauren Preston, Mohamed Morsy, Odayme Quesada and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current atherosclerosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Women's cardiovascular health in 2025:Saudi medical journal · 2026
    Review
  3. Review
  4. Spontaneous Coronary Artery Dissection in Women.Reviews in cardiovascular medicine · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cristiane C SingulaneDepartment of Medicine, Cardiovascular Division, University of Virginia Health, Charlottesville, VA, USA.
Shuo WangDepartment of Medicine, Cardiovascular Division, University of Virginia Health, Charlottesville, VA, USA.
Kelsey WattsDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.
Macy E StahlDepartment of Kinesiology, University of Virginia, Charlottesville, VA, USA.
LeAnn DenlingerDepartment of Medicine, Cardiovascular Division, University of Virginia Health, Charlottesville, VA, USA.
Rachel LloydOakland University William Beaumont School of Medicine, Rochester, MI, USA.
Pranavi PallintiSchool of Medicine, University of Virginia, Charlottesville, VA, USA.
Lauren PrestonDepartment of Medicine, Cardiovascular Division, University of Virginia Health, Charlottesville, VA, USA.
Mohamed MorsyDepartment of Medicine, Cardiovascular Division, University of Virginia Health, Charlottesville, VA, USA.
Odayme QuesadaDivision of Cardiovascular Health and Disease, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Angela TaylorDepartment of Medicine, Cardiovascular Division, University of Virginia Health, Charlottesville, VA, USA.
Randy K RamcharitarDepartment of Medicine, Cardiovascular Division, University of Virginia Health, Charlottesville, VA, USA.
Mete CivelekDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.
Patricia F Rodriguez-LozanoDepartment of Medicine, Cardiovascular Division, University of Virginia Health, Charlottesville, VA, USA. pr3gg@UVAHealth.org.

Funding

Identifying Inflammatory and Endothelial Mechanisms promoting Cardiac Deformation in Women with a History of PreeclampsiaR03HL177034 · THE CHRIST HOSPITAL · 2025 to 2025
$99k
NHLBI NIH HHS K23 HL151867NHLBI NIH HHS R03 HL177034
6 · The paper itself

Abstract

purpose of reviewSpontaneous coronary artery dissection (SCAD) is an underrecognized cause of acute coronary syndrome, primarily affecting younger women without traditional risk factors. This review synthesizes current knowledge, identifies research gaps, and explores how precision medicine can improve diagnosis, treatment, and patient outcomes. RECENT

findingsSCAD is clinically and biologically heterogeneous, with variation in presentation, etiology, and recurrence risk. Contributing factors include sex-specific hormonal differences, vascular abnormalities, genetic predisposition, psychosocial stressors, and social determinants of health. Despite growing awareness, major gaps persist in risk stratification and tailored care. Emerging tools, including genomics, radiomics, and multiomics, offer opportunities to define SCAD subtypes and personalized management. A precision medicine framework integrating molecular, imaging, and social data may transform SCAD care. Continued research is essential to improve early detection, optimize therapy, and reduce recurrence.

Indexed as

Acute Coronary SyndromeCoronary Vessel AnomaliesVascular DiseasesDissection, Blood VesselHumansPrecision MedicineRisk FactorsMultiomicsPrecision medicineSocial determinants of healthSpontaneous coronary artery dissection

Identifiers

PMID40815415
PMCPMC12356734

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.