Evidence map›Paper›PMID 40815832›Full record

ArticleJMIR research protocols2025

Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective Study.

Sinibaldo Romero Arocha, Kim Han, Rebecca D Huffstutler, Geethika P Thota, Natalie A Macheret, Amber B Courville, Robert J Brychta, Kong Y Chen, Stephanie T Chung, Laura C Coates and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04728165 (Pilot Study to Explore the Anti-Inflammatory Effects of Time-Restricted Feeding), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04728165 completednot on this map

Pilot Study to Explore the Anti-Inflammatory Effects of Time-Restricted Feeding

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2021 to 2023Enrolled27ConditionsPsoriasis, Systemic Inflammation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sinibaldo Romero ArochaKennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-6805-8792
Kim HanLaboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute Division of Intramural Research, Bethesda, MD, United States.ORCID 0000-0001-9092-9881
Rebecca D HuffstutlerCardiovascular Branch, National Heart, Lung, and Blood Institute Division of Intramural Research, Bethesda, MD, United States.ORCID 0000-0003-0029-8612
Geethika P ThotaDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States.ORCID 0000-0003-0438-8498
Natalie A MacheretDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States.ORCID 0009-0000-5409-1567
Amber B CourvilleDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States.ORCID 0000-0002-1419-3937
Robert J BrychtaDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States.ORCID 0000-0001-9491-7968
Kong Y ChenDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States.ORCID 0000-0002-0306-1904
Stephanie T ChungDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States.ORCID 0000-0001-6989-0417
Laura C CoatesKennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-4756-663X
Alexander J ClarkeKennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-2846-7860
Michael N SackLaboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute Division of Intramural Research, Bethesda, MD, United States.ORCID 0000-0002-3411-0000

Funding

Mitochondrial Biology in Cardiovascular DiseaseZ01HL005102 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2005 to 2008
$1.2M
Intramural NIH HHS Z01 HL005102NIDA NIH HHS Z99 DA999999
6 · The paper itself

Abstract

backgroundPsoriasis is a chronic inflammatory disease associated with multiple comorbidities, including metabolic syndrome and cardiovascular disease. Although specific dietary interventions, such as intermittent fasting and caloric restriction, have been shown to ameliorate inflammation and promote weight loss, the effect of these interventions independent of weight loss remains unclear. Time-restricted eating (TRE), a type of intermittent fasting, limits the daily eating window to a fixed number of hours. Recent studies suggest TRE may improve immune function in individuals with metabolic syndrome and cardiovascular risk factors. A crucial advantage of TRE over other investigated dietary restriction strategies is its reported high adherence rate, making it a more feasible intervention for long-term use. Therefore, exploring the effects of TRE on metabolic and immunological parameters in psoriasis is warranted.

objectiveThis study was designed to evaluate the effects of short-term, isocaloric TRE, independent of weight loss, on immune cell function and serum metabolite profiles of volunteers with mild-to-moderate psoriasis compared to healthy individuals.

methodsThis case-control, prospective study was performed on 10 healthy male participants and 10 age-, BMI-, and sex-matched individuals with mild-to-moderate psoriasis. All individuals with psoriasis had stable disease and were being treated with topical therapies without any exposure to immunomodulatory biologics. This study was conducted at the National Institutes of Health Clinical Center. Immune profiles, glucose handling, energy expenditure, and participants' weights were assessed at baseline and after 3 days of TRE following a daily 6-hour eating window and 18-hour fast.

resultsThe trial commenced in June 2021 and was completed in February 2023. A total of 20 participants were enrolled-10 with mild-to-moderate psoriasis and 10 age-, BMI-, and sex-matched healthy individuals. As of the time of manuscript submission, data processing is ongoing. Multiomic datasets, including gene expression, surface and intracellular protein levels, and metabolite profiles, are being generated from peripheral blood mononuclear cells, CD4

conclusionsThis clinical protocol was designed to characterize the effects of short term (3-day) TRE on psoriasis, independent of weight loss, by comparing immune cell regulatory responses between healthy individuals and those with psoriasis. More specifically, we aim to map the molecular pathways activated by TRE and assess how they affect immune cell composition, activation, and metabolism. Additionally, components of the metabolic response to isocaloric TRE are being explored. Insights into how dietary interventions impact metabolism and the immune system will enhance our understanding of the pathogenesis of psoriasis and may reveal new therapeutic avenues for managing this inflammatory condition.

trial registrationClinicalTrials.gov NCT04728165; https://clinicaltrials.gov/study/NCT04728165.

Indexed as

FastingInflammationPsoriasisAdultCase-Control StudiesFemaleHumansMaleMiddle AgedProspective StudiesWeight Losscalorie restrictionimmunometabolismimmunoregulationintermittent fastingpsoriasistime-restricted eating

Identifiers

PMID40815832
PMCPMC12397761

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.