Evidence map›Paper›PMID 40815853›Full record

ArticleThe American journal of sports medicine2025

Articular Cartilage Arthrokinematics and Compositional Measurements With qMRI 1 to 2 Years After ACL Reconstruction With Meniscal Surgery.

Sadegh Khodabandeloo, John C Ramsdell, Bruce D Beynnon, Mickey I Krug, Matthew Geeslin, Mathew J Failla, Rebecca H Choquette, Michael J DeSarno, Niccolo M Fiorentino

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In one paragraph

Article in The American journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Sadegh KhodabandelooDepartment of Mechanical Engineering, University of Vermont, Burlington, Vermont, USA.
John C RamsdellDepartment of Electrical and Biomedical Engineering, University of Vermont, Burlington, Vermont, USA.
Bruce D BeynnonDepartment of Orthopaedics and Rehabilitation, University of Vermont, Burlington, Vermont, USA.
Mickey I KrugDepartment of Orthopaedics and Rehabilitation, University of Vermont, Burlington, Vermont, USA.
Matthew GeeslinDepartment of Radiology, University of Vermont, Burlington, Vermont, USA.
Mathew J FaillaDepartment of Rehabilitation and Movement Science, University of Vermont, Burlington, Vermont, USA.
Rebecca H ChoquetteDepartment of Orthopaedics and Rehabilitation, University of Vermont, Burlington, Vermont, USA.
Michael J DeSarnoBiomedical Statistics Research Core, University of Vermont, Burlington, Vermont, USA.
Niccolo M FiorentinoDepartment of Mechanical Engineering, University of Vermont, Burlington, Vermont, USA.ORCID 0000-0003-0263-6769

Funding

The adaptive response of skeletal muscle, bone, and cartilage to severe knee trauma involving ACL disruption with and without concomitant injury to the meniscusR01AR076765 · NIAMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BEYNNON, BRUCE · 2020 to 2023
$1.6M
Biomechanical Markers of PTOA after ACL Reconstruction and Meniscal ResectionR21AR077371 · NIAMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FIORENTINO, NICCOLO M · 2021 to 2022
$521k
NIAMS NIH HHS R01 AR076765NIAMS NIH HHS R21 AR077371
6 · The paper itself

Abstract

backgroundPosttraumatic osteoarthritis (PTOA) often follows anterior cruciate ligament reconstruction (ACLR), especially when combined with meniscal surgery (ACLR+M). The mechanisms underlying development of PTOA remain unclear, including the early mechanical and compositional changes after surgery that potentially lead to irreversible cartilage degeneration. PURPOSE: To investigate the early effects of ACLR+M on joint arthrokinematics using dual-fluoroscopy with model-based tracking and cartilage composition using quantitative magnetic resonance imaging (qMRI). STUDY

designControlled laboratory study.

methodsTwelve participants who underwent ACLR+M were assessed 1 to 2 years after surgery. Dual-fluoroscopy with model-based tracking was used to quantify 6 degrees of freedom joint movements during walking and jogging. Arthrokinematics were assessed at 6% and 3% of the gait cycle for walk and jog, respectively, using magnetic resonance-based cartilage models. qMRI measured T1ρ relaxation times in the weightbearing tibial and femoral cartilage of both medial and lateral compartments.

resultsReconstructed knees showed increased anterior and lateral tibial translation during walking and jogging, larger abduction rotation during jogging, and a posterior shift of the tibiofemoral contact points on the tibia during walking relative to contralateral knees. The cartilage contact overlap area was increased in the medial compartment during walking in the reconstructed knee compared with the contralateral knee. Higher T1ρ relaxation times were observed in both medial and lateral femoral cartilages of the reconstructed knee compared with the contralateral knee. No correlation was found between reconstructed side-to-normal side differences in arthrokinematics and T1ρ relaxation times.

conclusionThese findings indicate early side-to-side differences in arthrokinematics and cartilage composition 1 to 2 years after ACLR with meniscal surgery, but patients with bigger side-to-side differences in arthrokinematics did not demonstrate bigger side-to-side differences in cartilage composition. CLINICAL RELEVANCE: Understanding mechanical and compositional differences after surgery, as well as the relationship between mechanics and composition, provides insight into their roles in PTOA initiation. This study underscores how ACLR with meniscal surgery affects tibiofemoral joint arthrokinematics and cartilage composition via qMRI. Results may provide insights into the early stages of PTOA and could inform postoperative strategies and/or targets for rehabilitation.

Indexed as

Anterior Cruciate Ligament ReconstructionCartilage, ArticularKnee JointMenisci, TibialOsteoarthritis, KneeAdultAnterior Cruciate Ligament InjuriesBiomechanical PhenomenaFemaleFluoroscopyHumansMagnetic Resonance ImagingMaleWalkingYoung AdultACLarthrokinematicscartilagemeniscusqMRI

Identifiers

PMID40815853
PMCPMC12756845

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.