ArticleBMC ophthalmology2025
Metabolomic insights into vitreous humor with therapy outcome in type 2 diabetic retinopathy.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Potential Molecular Biomarkers for Predicting and Monitoring Complications in Type 2 Diabetes Mellitus.Molecules (Basel, Switzerland) · 2025Review
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe therapeutic outcome for Type 2 Diabetic Retinopathy (T2DR) following vitrectomy has been unsatisfactory, with no definitive biomarker available to predict treatment response. Identifying a biomarker correlated with treatment efficacy is crucial, as the vitreous-situated between the lens and retina-may influence retinal metabolic perturbations.
methodsVitreous samples were collected during vitrectomy, and their metabolic profiles were analyzed using Ultraperformance Liquid Chromatography coupled with Tandem Mass Spectrometry (UPLC-MS/MS). Statistical analyses were conducted to identify metabolites and metabolic pathways correlated with therapeutic outcomes.
resultsPatients demonstrating poor therapeutic responses exhibited elevated levels of specific metabolites, including Dodecanoylcarnitine, Linoleylcarnitine, Stearylcarnitine, Decanoic acid, and Proline. Perturbed metabolic pathways included Fatty Acid Biosynthesis, Beta Oxidation of Very Long Chain Fatty Acids, and Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids. These metabolites showed strong discriminatory power for predicting positive outcomes, with Area Under the Curve (AUC) values of 0.925, 0.885, 0.864, 0.811, and 0.808, respectively.
conclusionsThis study highlights the potential of Dodecanoylcarnitine, Linoleylcarnitine, Stearylcarnitine, Decanoic acid, and Proline as biomarkers for predicting therapeutic outcomes following vitrectomy for T2DR. These findings provide novel insights into the metabolic factors influencing treatment response variability and suggest pathways for future therapeutic interventions.
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