ArticleBMC geriatrics2025
Association between estimated glomerular filtration rate and memory function mediated by brain Gray matter volumes: a cross-sectional study using the ADNI database.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Kidney function and brain health: cognitive and structural signatures across cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Comparative characteristics of homocysteine and uric acid in patients with Parkinson's disease-related cognitive impairment and post-stroke cognitive impairment.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundEstimated glomerular filtration rate (eGFR) is associated with gray matter volumes (GMVs) in memory-related regions, but its relationship with memory function and the mediating role of GMVs remain unclear. We aimed to investigate whether eGFR levels are associated with memory function and whether GMVs mediate this association.
methodsThis study utilized data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Participants were categorized into eGFR quartiles. Memory function was assessed using the ADNI composite memory score (ADNI_MEM). GMVs were normalized to total intracranial volume. Multivariate linear regression models examined associations between eGFR, GMVs, and memory function. Structural equation modeling (SEM) assessed the mediating role of GMVs.
resultsA total of 1311 older adults were included. Higher eGFR was associated with better memory function (adjusted β = 0.33, 95% CI: 0.14-0.50), particularly in mild cognitive impairment (MCI) patients (adjusted β = 0.45, 95% CI: 0.23-0.67). Higher eGFR was also associated with larger GMVs in key memory-related regions, including the hippocampus, entorhinal cortex, fusiform gyrus, and middle temporal gyrus (all P < 0.001). GMVs significantly mediated the relationship between eGFR and memory function (all mediation P < 0.05).
conclusionsHigher eGFR levels are positively associated with memory performance, particularly in individuals with MCI, and this association is mediated by GMVs. These findings suggest that renal function may be a critical factor in memory decline risk assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.