Evidence map›Paper›PMID 40817300›Full record

ArticleJournal of cancer survivorship : research and practice2025

Exercise-induced symptoms in young childhood cancer survivors.

Maša Žarković, Carina Nigg, Christina Schindera, Myrofora Goutaki, Sonja Lüer, Marc Ansari, Claudia E Kuehni

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In one paragraph

Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cohort Profile Update: The Swiss Childhood Cancer Survivor Cohort.International journal of epidemiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maša ŽarkovićChildhood Cancer Research Group, Institute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Carina NiggChildhood Cancer Research Group, Institute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Christina SchinderaChildhood Cancer Research Group, Institute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Myrofora GoutakiChildhood Cancer Research Group, Institute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Sonja LüerDivision of Pediatric Hematology and Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, Bern, Switzerland.
Marc AnsariDivision of Pediatric Oncology and Hematology, Department of Women, Child and Adolescent, University Hospital of Geneva, Geneva, Switzerland.
Claudia E KuehniChildhood Cancer Research Group, Institute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland. claudia.kuehni@unibe.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExercise-induced symptoms (EIS) are common in children and understudied in childhood cancer survivors (CCS). We assessed the prevalence of EIS in CCS and identified associated risk factors.

methodsWe included CCS aged 6-21 years who were diagnosed with cancer ≥ 1 year before study entry, were treated with systemic anticancer treatment, chest surgery, radiotherapy, or hematopoietic stem cell transplantation, completed cancer treatment, and received pediatric oncology follow-up care. Participants completed a questionnaire on respiratory symptoms and lifestyle. To explore risk factors of EIS, we used multivariable logistic regression and calculated population attributable fractions (PAFs).

resultsOf 196 participants (median age 14 years [IQR 10-17]), 46 (24%) reported EIS, including dyspnea (14%), cough (12%), and wheeze (7%). EIS were more common among females (OR 2.5, 95% CI 1.1-5.9), older survivors (OR 1.2 per year, 95% CI 1.1-1.3,), and those with obesity (OR 4.7, 95% CI 1.1-19.6), asthma (OR 10.1, 95% CI 3.3-31.2), and physical inactivity (OR 2.9, 95% CI 1.3-6.6). Chest-directed radiotherapy tended also to increase the risk (OR 2.4, 95% CI 0.6-9.2). Twenty percent of EIS were attributable to asthma, 18% to physical inactivity, and 7% to obesity, with a combined PAF of 44%.

conclusionsEIS affect one in four CCS and are primarily associated with risk factors common in the general population rather than cancer treatments. IMPLICATIONS FOR CANCER SURVIVORS: Clinical investigation and management of common causes of EIS, particularly asthma, physical inactivity, and obesity, could reduce symptom burden and support long-term health in CCS.

Indexed as

Childhood cancer survivorDyspneaPhysical activityRespiratory health

Identifiers

PMID40817300

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.