Evidence map›Paper›PMID 40817681›Full record

ArticleExperimental dermatology2025

Suppression of Sebum Production by Vemurafenib Through Paradoxical ERK Activation Resulted in the Inhibition of the mTOR Pathway in 5α-Dihydrotestosterone-Differentiated Hamster Sebocytes In Vitro.

Toshikazu Koiwai, Takashi Sato

Abstract read
In one paragraph

Article in Experimental dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Toshikazu KoiwaiDepartment of Biochemistry, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.ORCID https://orcid.org/0009-0000-9847-8931
Takashi SatoDepartment of Biochemistry, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.ORCID https://orcid.org/0000-0003-0687-9696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vemurafenib, a low-molecular-weight BRAF inhibitor, effectively treats cutaneous melanoma with the BRAF

Indexed as

Extracellular Signal-Regulated MAP KinasesIndolesSebaceous GlandsSebumSulfonamidesTOR Serine-Threonine KinasesAnimalsButadienesCell DifferentiationCricetinaeDihydrotestosteroneMaleMAP Kinase Signaling SystemMesocricetusNitrilesPhosphorylationButadienesDihydrotestosteroneExtracellular Signal-Regulated MAP KinasesIndolesNitrilesSulfonamidesTOR Serine-Threonine KinasesU 0126Vemurafenib5α‐dihydrotestosteroneextracellular signal‐regulated kinasemechanistic target of rapamycinsebaceous glandsvemurafenib

Identifiers

PMID40817681
PMCPMC12357165

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.