Evidence map›Paper›PMID 40817903›Full record

ArticleJACC. Asia2026

Accelerated Biological Aging, Genetic Predisposition, and Incident Valvular Heart Disease.

Yong-Jian Zhu, Xiang-Ying Suo, Jing Guo, Shuo Lu, Jun-Xi Zhang, Ya-Cong Bo, Zhan-Ying Han, Chun-Guang Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yong-Jian ZhuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiang-Ying SuoSchool of Public Health, Zhengzhou University, Zhengzhou, China.
Jing GuoSchool of Physical Education (Main Campus), Zhengzhou University, Zhengzhou, China.
Shuo LuSchool of Public Health, Zhengzhou University, Zhengzhou, China.
Jun-Xi ZhangNHC Key Laboratory of Birth Defects Prevention, Henan Key Laboratory of Population Defects Prevention, Zhengzhou, China.
Ya-Cong BoSchool of Public Health, Zhengzhou University, Zhengzhou, China; NHC Key Laboratory of Birth Defects Prevention, Henan Key Laboratory of Population Defects Prevention, Zhengzhou, China.
Zhan-Ying HanDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: hzy91@163.com.
Chun-Guang QiuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: fccqiucg@zzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between biological aging and valvular heart disease (VHD) has not yet been evaluated.

objectivesThis study aimed to evaluate the associations between 2 biological age indicators, Klemera-Doubal method biological age (KDM-BA) acceleration and PhenoAge acceleration, and the risk of VHD, as well as explore the potential gene-environment interplay.

methodsThe study included 341,460 UK Biobank participants without VHD at enrollment. Biological age was assessed using KDM-BA and PhenoAge methods. Genetic risk was measured by genome-wide-association study-based polygenic risk scores (PRS). Cox models were used to assess the individual and joint effects of biological age and PRS on incident VHD. Both multiplicative and additive interactions between the 2 factors were also estimated.

resultsDuring a median follow-up of 13.58 years (Q1-Q3: 12.83-14.25 years), 8,146 VHD cases were documented. The results showed a significant association between older biological age and an increased risk of VHD, with a HR of 1.35 (95% CI: 1.32-1.38) for each 1-SD increase in KDM-BA acceleration, and 1.29 (95% CI: 1.26-1.32) for PhenoAge acceleration. Compared with individuals in the first quartile group (Q1) for KDM-BA acceleration, those in Q4 showed the highest risk of VHD, with an 86% higher risk (HR: 1.86; 95% CI: 1.74-1.99). There was an additive interaction between KDM-BA acceleration and PRS for VHD. Similar results were found for the association between PhenoAge acceleration and VHD.

conclusionsAdvanced biological aging was significantly associated with an increased risk of VHD and could serve as a potential target for clinical prediction and intervention.

Indexed as

biological agegenetic predispositionKDM-BA accelerationPhenoAge accelerationvalvular heart disease

Identifiers

PMID40817903
PMCPMC12833606

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.