ArticleBMC cancer2025
Impact of loneliness on depression among cancer survivors: a comparison between adolescents and young adults and other age groups.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Online peer support for breast cancer survivors: protocol for a decentralized multicenter open-label pilot randomized controlled trial (HOPE-BC study).International journal of clinical oncology · 2026Article
- Adolescent and young adult cancer survivor experiences of financial toxicity: a scoping review.Journal of cancer survivorship : research and practice · 2026Review
- Association between loneliness and social isolation and health outcomes among cancer survivors and non-cancer controls.Frontiers in aging · 2026Article
- 'What Really Goes on in My Cancer Bubble, They Cannot Understand': Social Functioning Among Adolescent and Young Adult (AYA) Cancer Patients.Current oncology (Toronto, Ont.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundNumerous studies have suggested an association between loneliness and depression in cancer survivors, particularly adolescents and young adults (AYAs). This study aimed to develop a causal model linking loneliness to depression using structural equation modeling.
methodsA cross-sectional web-based survey was conducted to collect demographic information and psychosocial measures, including the UCLA Loneliness Scale, Patient Health Questionnaire-9, EQ-5D-5L, Multidimensional Scale of Perceived Social Support short form, Brief Resilience Scale, Comprehensive Score for Financial Toxicity, and a single item on cancer-related stigma. Structural equation modeling with observed variables was conducted, focusing on the pathway from loneliness to depression. Multiple-group analysis was used to compare AYAs and non-AYAs.
resultsThe study included 3,565 cancer survivors, of whom 743 (20.8%) were AYAs. The final model showed a significant association between loneliness and depression (standardized coefficient = 0.214; 95% confidence interval = 0.184–0.243; P < 0.001). Perceived social support, resilience, financial toxicity, and stigma were directly or indirectly related to loneliness and depression. Female sex and having a spouse or partner were associated with perceived social support, whereas non-job-related social participation was associated with loneliness. The association between loneliness and depression was significantly stronger among AYAs than non-AYAs.
conclusionsThe results suggested a significant link between loneliness and depression, with a stronger pathway in AYAs. Loneliness may serve as a modifiable mediator for interventions targeting depression prevention among AYA cancer survivors. The psychosocial variables identified could aid in screening high-risk individuals and developing effective interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.