Evidence map›Paper›PMID 40819335›Full record

ArticleDiscover oncology2025

FLASH radiotherapy at a crossroads: a bibliometric perspective on progress and challenges.

Peng Wang, Yugeng Gao, Can Chen, Xiaoxin Zhao, Yuying Zhang, Taorui Liu, Haoran Jiang, Zhe Wang, Xiang Zhao, Jianjun Li

Abstract read
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peng Wang *Department of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Yugeng Gao *JCCU Translational Surgical Oncology (A430), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Can ChenDepartment of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Xiaoxin ZhaoDepartment of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Yuying ZhangDepartment of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Taorui LiuDepartment of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Haoran JiangDepartment of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Zhe WangDepartment of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Xiang ZhaoDepartment of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. zhaoxiang@tmmu.edu.cn.
Jianjun LiDepartment of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. jianjunli@tmmu.edu.cn.

Funding

Chongqing medical scientific research project 2024QNXM007DOCTOR-ENTRANCE program CSTB2022BSXM-JSX0002
6 · The paper itself

Abstract

backgroundFlash radiotherapy (FLASH-RT), an emerging modality utilizing ultra-high dose-rate (UHDR) irradiation (typically > 40 Gy/s), has demonstrated a unique capacity to preserve normal tissue integrity while maintaining tumor control efficacy compared to conventional radiotherapy. Despite exponential growth in FLASH-RT research over the past decade, its scientific landscape has not yet been systematically characterized through bibliometric analysis. This study only includes articles from the Web of Science Core Collection (WoSCC) and is limited to English-language publications, which may introduce database and language biases.

methodsRelevant articles and reviews on FLASH-RT were retrieved from the WoSCC database. Bibliometric analysis and scientific knowledge mapping were performed using the R packages Bibliometrix, CiteSpace, and VOSviewer, in conjunction with the online analytical tools provided by Web of Science (WoS).

resultsA total of 572 publications from 2013 to 2025, spanning 179 countries/regions and involving 2,049 institutions, were analyzed. The United States, Switzerland, and China were the leading contributors. The University of Lausanne had the highest research output. These publications appeared in 96 different journals, with Medical Physics contributing the most studies. Among 2995 authors, Vozenin MC had the highest publication count and H-index, while Favaudon V's papers received the most citations. Frequent keywords included irradiation, flash radiotherapy, radiation therapy, and cells. Keyword clustering revealed eleven major research directions, primarily focusing on pencil beam scanning and dosimetry.

conclusionThis first bibliometric analysis of FLASH-RT research highlights key trends, influential contributors, and challenges. These findings provide valuable insights into research frontiers and hotspots, guiding future studies and collaborations.

Indexed as

Bibliometric analysisCiteSpaceFLASH radiotherapyUltra-high dose-rateVOSviewerWeb of science

Identifiers

PMID40819335
PMCPMC12358346

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.