SynthesisOpen heart2025
Prevalence and associated outcomes of right ventricular dysfunction in peripartum cardiomyopathy: a systematic review, meta-analysis and meta-regression.
Synthesis in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecent studies have highlighted the presence of right ventricular dysfunction (RVD) in a substantial proportion of peripartum cardiomyopathy (PPCM), with evidence suggesting that RVD is associated with worse outcomes and a lower likelihood of left ventricular (LV) recovery. This study aims to comprehensively assess the pooled prevalence, associated outcomes and LV recovery of RVD in PPCM.
methodsPubMed, Scopus and ScienceDirect were used to identify relevant literature prior to 19 January 2025. Statistical analysis was conducted using RStudio. All meta-analyses were performed using random effects, with subsequent subgroup analysis and univariate meta-regression conducted for prevalence meta-analysis.
resultsThe pooled prevalence of RVD in PPCM was 0.48 (95% CI: 0.36 to 0.59; I² 95.3%) across 14 studies (1385 patients). RVD was diagnosed using multimodality imaging (e.g., echocardiography and cardiac magnetic resonance imaging), with diagnostic criteria defined in the original studies. Meta-regression showed a decreasing trend in RVD prevalence in more recent publications (p=0.03), with variability based on study design, location and diagnostic modality on subgroup analysis. Patients with RVD had a significantly higher risk of composite adverse outcomes (including death, LV assist device implantation, heart transplantation or the use of extracorporeal membrane oxygenation; hazard ratio 2.71; 95% CI 1.08 to 6.84; p=0.04; three studies) and heart transplantation (risk ratio (RR) 4.71; 95% CI 1.82 to 12.20; p<0.01; two studies). Additionally, RVD was associated with a lower baseline LV ejection fraction (mean difference -10.94; 95% CI -14.80 to -7.08; p<0.01; six studies) and an increased risk of unrecovered LV function (RR 1.62; 95% CI 1.25 to 2.11; p<0.01; four studies).
conclusionRVD occurs in nearly half of patients with PPCM and is associated with a poor prognosis. It may represent a crucial marker for prognostic stratification, particularly for the risk of unrecovered LV function. PROSPERO REGISTRATION NUMBER: CRD42025626739.
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