ArticleScientific reports2025
Utility of 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde in the synthesis of novel 1,3,4-thiadiazoles or 1,3-thiazoles and study their cytotoxic activity.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
One of the biggest causes of death around the world is cancer. Despite the development of a variety of chemotherapeutic drugs that stop excessive cell division, drug resistance remains a major obstacle to chemotherapy. It is consequently critical to develop and find new and effective anti-cancer agents in order to address the global threat. Owing to coumarins are a promising scaffold for anticancer agents, in this approach, we interested to synthesis new coumarins linked to either 1,3-thiazols or 1,3,4-thiadiazoles and examined their cytotoxic efficacy. Eleven of the newly prepared compounds were selected for the in vitro anticancer investigations against 60 human cancer cell lines at a single dose (10
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