Evidence map›Paper›PMID 40820160›Full record

ArticleScientific reports2025

Modulation of retinal inflammation delays degeneration in a mouse model of geographic atrophy.

Raela B Ridley, Brianna M Tischner, Jieun Lee, Erin Walsh, Michael T Massengill, Alfred S Lewin, Cristhian J Ildefonso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Raela B Ridley *Department of Ophthalmology, University of Florida College of Medicine, PO Box 100284, Gainesville, FL, 32610, USA.
Brianna M Tischner *Department of Ophthalmology, University of Florida College of Medicine, PO Box 100284, Gainesville, FL, 32610, USA.
Jieun LeeDepartment of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Erin WalshDepartment of Ophthalmology, University of Florida College of Medicine, PO Box 100284, Gainesville, FL, 32610, USA.
Michael T MassengillDepartment of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Alfred S LewinDepartment of Ophthalmology, University of Florida College of Medicine, PO Box 100284, Gainesville, FL, 32610, USA.
Cristhian J IldefonsoDepartment of Ophthalmology, University of Florida College of Medicine, PO Box 100284, Gainesville, FL, 32610, USA. ildefons@ufl.edu.

Funding

RESEARCH TRAINING IN VISION SCIENCET32EY007132 · NEI · UNIVERSITY OF FLORIDA · PI W CLAY SMITH · 1991 to 2026
$3.8M
Testing Gene Therapy in Models of Geographic AtrophyR01EY026268 · NEI · UNIVERSITY OF FLORIDA · PI LEWIN, ALFRED S · 2016 to 2020
$2.6M
Core Equipment for Assessment of Ocular Disease in Animal ModelsS10OD028476 · OD · UNIVERSITY OF FLORIDA · PI SMITH, W CLAY · 2020 to 2020
$348k
Bright Focus Foundation M2017126National Eye Institute,United States EY026268NEI NIH HHS R01 EY026268NEI NIH HHS S10OD028476NEI NIH HHS T32 EY007132NIH HHS S10 OD028476
6 · The paper itself

Abstract

Geographic atrophy, the advanced form of age-related macular degeneration (AMD), is associated with increased oxidative stress and chronic inflammation. Pro-inflammatory genes, like TNF-α and IL-1β, are under the regulation of the transcription factor p65/RelA. We have previously shown that adeno-associated virus (AAV) delivery of the RelA inhibitory gene M013 blocks retinal inflammation in uveitis models. In this study, we evaluated the effects of RelA inhibition in an oxidative stress-driven geographic atrophy mouse model. We injected Sod2

Indexed as

Geographic AtrophyInflammationRetinitisAnimalsDependovirusDisease Models, AnimalElectroretinographyMiceMicrogliaNF-kappa BOxidative StressRetinaTranscription Factor RelANF-kappa BRela protein, mouseTranscription Factor RelAAge-related macular degenerationMyxoma virusNF-kBRetinal inflammation

Identifiers

PMID40820160
PMCPMC12358612

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.