Evidence map›Paper›PMID 40820378›Full record

ArticleEuropean journal of immunology2025

Mast Cells Are Not Essential for Pubertal Mammary Gland Branching.

Simran Kapoor, Clara M Munz, Jimmy Marsden, Cyril Carvalho, Holly Tinsley, Marlene Magalhaes Pinto, Bert Malengier-Devlies, Solvig Becker, Guillaume Seuzaret, Katelyn Patatsos and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Simran KapoorInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.
Clara M MunzInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-4823-7598
Jimmy MarsdenInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.
Cyril CarvalhoInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.
Holly TinsleyInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.
Marlene Magalhaes PintoInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.
Bert Malengier-DevliesInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-3527-1145
Solvig BeckerInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.
Guillaume SeuzaretInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.
Katelyn PatatsosInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-9980-8349
Ramazan AkyolAix-Marseille University, CNRS, INSERM, Centre d'immunologie De Marseille-Luminy (CIML), Marseille, France.
Amy B PedersonInstitute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Gillian WilsonInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.ORCID 0000-0002-9513-8437
Marc DalodAix-Marseille University, CNRS, INSERM, Centre d'immunologie De Marseille-Luminy (CIML), Marseille, France.
Rebecca GentekInstitute For Regeneration and Repair, Centre For Reproductive Health, Centre For Inflammation Research, University of Edinburgh, Edinburgh, UK.

Funding

Cancer Research UKCollege of Medicine and Veterinary Medicine, University of Edinburgh: Chancellor's FellowshipKennedy Trust for Rheumatology Research: Senior Research Fellowship KENN 19 20 07Pathogen & Global Health PhD studentshipWellcome Trust: Host
6 · The paper itself

Abstract

Mast cells are long-lived, tissue-resident immune cells of the myeloid lineage with cardinal functions in allergy and atopic disease. They are now increasingly recognized also for protective roles, for example against infections and venoms. Other functions originally assigned to mast cells in development and physiology, however, have been refuted, and for yet others, the true contribution of mast cells remains uncertain. Mast cells have been implicated in promoting ductal branching in the pubertal mammary gland, the organ that produces and secretes milk in mammals, but these findings are based on mouse models that are not mast cell-specific. In this study, we therefore re-addressed the impact of mast cells on mammary gland branching using several complementary genetic models, including a newly generated transgenic mouse line (Ms4a2

Indexed as

Mammary Glands, AnimalMast CellsSexual MaturationAnimalsFemaleMiceMice, Inbred C57BLMice, KnockoutMice, Transgenicbranchingmammary glandmast cellspuberty

Identifiers

PMID40820378
PMCPMC12358710

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.