ArticleMolecular plant pathology2025
Phytophthora Avr3a-Like Effectors Target and Inhibit Cinnamyl Alcohol Dehydrogenase CAD5 to Suppress Plant Immunity.
Article in Molecular plant pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Late Blight Effector Pi05910 Suppresses Plant Immunity by Promoting Destabilisation of Host Scaffold Protein RACK1.Molecular plant pathology · 2026Article
- Genomic Insights into Adaptation ofPlants (Basel, Switzerland) · 2026Article
- Phytophthora Avr3a-Like Effectors Target and Inhibit Cinnamyl Alcohol Dehydrogenase CAD5 to Suppress Plant Immunity.Molecular plant pathology · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Phytophthora species are oomycetes that cause significant losses in agricultural production and damages to natural ecosystems. Phytophthora pathogens secrete numerous cytoplasmic effectors that target distinct cellular components to suppress host immunity and facilitate pathogen colonisation. The identification of their host targets is crucial for deciphering the mechanisms they employ to modulate host immunity. Here, we found that multiple Phytophthora Avr3a-like effectors interact with host plant cinnamyl alcohol dehydrogenase CAD5, as revealed by yeast two-hybrid and co-immunoprecipitation assays. Analysis of Arabidopsis thaliana T-DNA insertion mutants and overexpression lines, as well as analysis of RNA silencing Nicotiana benthamiana plants, showed that CAD5 positively regulates plant immunity to Phytophthora pathogens. Overexpression and silencing analyses showed that CAD5 plays a positive role in plant PAMP-triggered immunity (PTI) responses, including enhanced callose deposition, promoted cell death induced by INF1, and in plant effector-triggered immunity (ETI) responses mediated by R3a/PiAvr3a
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.