ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Cellular Responses to Nanoscale Topography Mediated Through the RhoA/ROCK Pathway.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Topographical design principles for osteochondral tissue engineering.Bioactive materials · 2026Review
- Disordered Glass Nanowire Substrates Produce in Vivo-Like Astrocyte Morphology Revealed by Low-Coherence Holotomography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cellular Responses to Nanoscale Topography Mediated Through the RhoA/ROCK Pathway.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Nanotopography exhibits strong effects on cellular properties such as cytoskeletal organization and endocytosis. Responses to topographical cues can propagate into cell-scale characteristics like cortical stiffness as well as systemic effects like inflammation and implant rejection; however, the biological pathways governing these effects remain comparatively unknown. Here we show how the RhoA/ROCK pathway can regulate responses to nanotopographical features vis-à-vis cellular tension. 2D arrays of hemispherical gold nanoparticles are combined with epithelial cells to determine how up- and down-regulating RhoA activity influences cellular responses. It is found that higher RhoA activity correlates with increased tension and decreased membrane conformality, actin reorganization, and endocytosis. Also, increased tension produces large focal adhesions in cells not typically observed from substrate patterns. Conversely, reducing tension by lowering RhoA activity results in increased membrane conformality around the nanoparticles as well as actin and endocytosis colocalization with nanoparticle sites. This study provides a critical connection between biomolecular regulators of cell mechanics, in particular RhoA, and cellular responses to nanoscale topographical features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.