Evidence map›Paper›PMID 40820950›Full record

ArticleInternational journal of circumpolar health2025

Cross-over comparative study of cold-induced brown adipose tissue activity in Greenlandic Inuit and Danes: rationale, design, and methodology.

Mette Motzfeldt Jensen, Charlotte Elberling Almasi, Benedict Kjærgaard, Bodil Steen Rasmussen, Thure Haunstrup, Sille Ulrik Thomsen, Mette K Andersen, Torben Hansen, Christina Ellervik, Camilla Schéele and 2 more

Abstract readComparative Study
In one paragraph

Article in International journal of circumpolar health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mette Motzfeldt JensenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.ORCID 0009-0009-4129-2218
Charlotte Elberling AlmasiDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.ORCID 0000-0002-0720-9160
Benedict KjærgaardDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.ORCID 0000-0001-5797-7638
Bodil Steen RasmussenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.ORCID 0000-0003-2190-145X
Thure HaunstrupDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.ORCID 0000-0002-5190-4857
Sille Ulrik ThomsenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Mette K AndersenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8227-1469
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8748-3831
Christina EllervikDepartment of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark.ORCID 0000-0002-3088-4375
Camilla SchéeleNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6055-9709
Marit Eika JørgensenGreenland Center for Health Research, Ilisimatusarfik, University of Greenland, Nuuk, Greenland.ORCID 0000-0001-8356-5565
Stig AndersenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.ORCID 0000-0003-3632-5213

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brown adipose tissue (BAT) is essential for non-shivering thermogenesis, a key survival mechanism for Arctic populations exposed to chronic cold. As BAT dissipates energy as heat, it presents a potential target for improving cardiometabolic health and treating obesity. The Arctic Inuit represents a unique metabolic model due to distinct genetic and environmental adaptations. This study advances methods in cardiometabolic research by investigating BAT activation in Arctic Inuit and ethnic Danes under cold exposure. A comparative crossover study of 20 Inuit and Danes includes two sessions: (A) thermal comfort and (B) 2 hours of individualised cooling. Each session concludes with fat biopsies and [

Indexed as

Adipose Tissue, BrownCold TemperatureInuitThermogenesisAdultArctic RegionsCross-Over StudiesDenmarkFemaleGreenlandHumansMaleMiddle AgedPositron Emission Tomography Computed TomographyResearch DesignScandinavians and Nordic Peoplebeige adipose tissueBrown adipose tissue (BAT)cardiometabolic healthcold adaptationcold metabolismobesity

Identifiers

PMID40820950
PMCPMC12364086

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.