ReviewFrontiers in psychiatry2025
Meta-analysis of the effect of vitamin D on depression.
Review in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Serum 25-Hydroxyvitamin D and Depressive Symptoms in a 12-Year Korean Occupational Cohort: A Threshold Effect Confined to Severe Deficiency.Nutrients · 2026Article
- [Vitamin D supplementation in depression-Meaningful, evidence-based or guideline-compliant?]Der Nervenarzt · 2026Review
- Vitamin D and Postpartum Depression: A Narrative Review.Clinics and practice · 2026Review
- Article
- Vitamin D and exercise in obesity: a neurovascular-muscle axis.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the effect of vitamin D supplementation on depressive symptoms by conducting a meta-analysis of randomized controlled trials. Methods: We systematically searched PubMed, EMBASE, the Cochrane Library, CNKI, VIP, Wanfang, and additional databases for relevant literature published between January 1, 2000, and October 31, 2024. Two independent reviewers screened titles, abstracts, and full texts, extracted data, and assessed study quality. RevMan 5.3 software was employed to calculate pooled effect sizes and assess heterogeneity. Results: Twenty trials met our inclusion criteria. Meta-analysis using a random-effects model demonstrated that vitamin D supplementation significantly reduced depressive symptom scores compared to controls (standardized mean difference [SMD] = -0.36; 95% confidence interval [CI], -0.52 to -0.20; P < 0.00001). Conclusion: Our findings indicate that vitamin D supplementation is associated with a moderate but statistically significant improvement in depressive symptoms. These results support the potential role of vitamin D as an adjunctive treatment for depression, particularly in individuals with baseline deficiency.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.