Evidence map›Paper›PMID 40821749›Full record

ReviewDiabetes, metabolic syndrome and obesity : targets and therapy2025

Advances in the Role of Stem Cell-Derived Exosomes in Diabetic Foot Wound Healing.

Junbo Wang, Yu-Jie Liang, Xiaohua Pan

Abstract readReview
In one paragraph

Review in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Advances in Stem Cell Therapy for Diabetic Foot Ulcers.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Junbo WangDepartment of Orthopaedics and Traumatology, The Second Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China.ORCID 0009-0000-4787-6294
Yu-Jie LiangThe Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Xiaohua PanDepartment of Orthopaedics and Traumatology, The Second Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hyperglycemia over a long period can lead to diabetes-related complications, of which diabetic foot ulcers continue to have a huge economic and social impact worldwide. Mesenchymal stem cell-derived exosomes (MSC-Exos) have demonstrated positive efficacy in the preclinical research and clinical trial phases of diabetic foot ulcer (DFU) treatment. In this review, we provide a brief overview of the properties of MSC-derived exosomes and their biological functions, summarize the therapeutic efficacy of Exos in the treatment of diabetic foot ulcers and its mechanism of action, and discuss innovative technologies including hydrogel scaffolds and 3D bioprinting to enhance the effectiveness of MSC - Exos in the treatment of diabetic foot ulcers. This paper also explores the application of innovative technologies such as hydrogel scaffolds and 3D bioprinting in enhancing the efficacy of MSC-Exos in the treatment of diabetic foot ulcers and highlights the key challenges faced in translating these advanced technologies from the laboratory to the clinic.

Indexed as

chronic woundsdiabetic foot ulcersstem cell-derived exosomestissue engineeringtranslational research

Identifiers

PMID40821749
PMCPMC12350548

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.