ReviewFrontiers in cardiovascular medicine2025
Cardioepigenetics in action: aerobic exercise-induced modulation of miRNAs, lncRNAs, and chromatin remodeling in cardiovascular disease.
Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Long non-coding RNAs in exercise: the hidden regulators of adaptation.Pflugers Archiv : European journal of physiology · 2026Review
- Exercise-Induced Regulation of LncRNAs: Mechanistic Insights and Clinical Translation in Cardiovascular Health.Journal of cardiovascular translational research · 2026Review
- Device-measured physical activity and cardiovascular risk among cardiomyopathy variant carriers in the all of us research program.American journal of preventive cardiology · 2026Article
- Review
- Exercise-induced microRNAs: molecular pathways and adaptive remodeling of skeletal muscle.Pflugers Archiv : European journal of physiology · 2026Review
- MicroRNAs in Heart Failure Pathogenesis and Progression: Mechanistic Control, Biomarker Potential, and Translational Perspectives.Life (Basel, Switzerland) · 2026Review
- Mitochondria: the central hub linking exercise to enhanced cardiac function.Frontiers in physiology · 2026Review
- Cardiac biomarkers in athletes and active individuals: a clinical review of exercise-induced elevations and diagnostic interpretation.Frontiers in physiology · 2026Review
- Epigenetic advances in rheumatic heart disease.Journal of translational autoimmunity · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, despite advances in prevention and therapy. Emerging evidence highlights the central role of epigenetic modifications and non-coding RNAs including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the regulation of gene expression networks underlying cardiovascular homeostasis and disease. Concurrently, physical exercise has been recognized not only as a preventive and therapeutic strategy for CVDs but also as a potent modulator of epigenetic landscapes. This review explores the mechanistic links between aerobic exercise and epigenetic modulation, focusing on how structured physical activity influences the expression and function of miRNAs and lncRNAs, as well as chromatin remodeling processes in cardiovascular tissues. We provide a comprehensive overview of aerobic exercise-responsive non-coding RNAs implicated in vascular inflammation, endothelial function, cardiac remodeling, myocardial infarction, and atherosclerosis. Additionally, we discuss aerobic exercise-induced changes in DNA methylation and histone modification patterns that contribute to transcriptional reprogramming and long-term cardiovascular benefits. Finally, the review evaluates the translational potential of targeting aerobic exercise-regulated epigenetic factors for early diagnosis, risk stratification, and personalized therapies in CVD management. Understanding the molecular underpinnings of cardioepigenetic responses to exercise opens promising avenues for precision cardiovascular medicine and integrative therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.