Evidence map›Paper›PMID 40822235›Full record

ArticleERJ open research2025

C-BIOPRED severe asthma clinical phenotypes: link to complement and coagulation pathways and galectin 10.

Changxing Ou, Zhenan Deng, Yongkang Liao, Xiaomin Cen, Penghui Wu, Chenyang Lu, Xiuhua Fu, Changzheng Wang, Meilin Jin, Guochao Shi and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Changxing OuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.ORCID https://orcid.org/0000-0002-9993-4617
Zhenan DengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Yongkang LiaoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Xiaomin CenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Penghui WuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Chenyang LuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Xiuhua FuDepartment of Respiratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China.
Changzheng WangDepartment of Respiratory Medicine, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Meilin JinDepartment of Respiratory Medicine, Zhongshan Hospital, Shanghai, China.
Guochao ShiDepartment of Respiratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhongmin QiuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-6612-7413
Xiaoyang WeiDepartment of Respiratory Medicine, The Eighth Medical Center of PLA General Hospital, Beijing, China.
Wei GuDepartment of Respiratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Jian KangDepartment of Respiratory Medicine, The First Hospital of China Medical University, Shenyang, China.
Yunhui ZhangDepartment of Respiratory Medicine, The First people's Hospital of Yunnan Province, Kunming, China.
Mao HuangDepartment of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jinfu XuDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Shanghai, China.ORCID https://orcid.org/0000-0002-8039-8973
Kewu HuangDepartment of Respiratory Medicine, Beijing Chao-Yang Hospital, Beijing, China.
Qiang LiDepartment of Respiratory Medicine, Shanghai General Hospital, Shanghai, China.
Xiangyan ZhangDepartment of Respiratory Medicine, Guizhou Province People's Hospital, Guiyang, China.
Chunhua WeiDepartment of Respiratory Medicine, Weifang Weien Hospital, Weifang, China.
Guangfa WangDepartment of Respiratory Medicine, Peking University First Hospital, Beijing, China.
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-7101-1426
Nanshan ZhongState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Qingling ZhangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Jiaxing XieState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.ORCID https://orcid.org/0000-0001-6462-6676

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Severe asthma is a heterogeneous airway inflammatory disease presenting with varying clinicophysiological characteristics and response to treatments. The objectives of the present study were to determine the clinical phenotypes of the Chinese C-BIOPRED cohort and their link to the sputum proteome. Methods: Partition-around-medoids clustering was applied to a training set of 362 nonsmoking, smoking or ex-smoking severe asthma patients, and nonsmoking mild-moderate asthma patients using eight clinicophysiological variables, with validation performed in the remaining 181. Results: Three stable clusters were defined, with Cluster T1 composed of predominantly female patients with severe nonsmoking asthma experiencing frequent exacerbations with moderate airflow obstruction, and Cluster T3 of elderly male patients with smoking/ex-smoking late-onset severe asthma and severe airflow obstruction and a moderate number of exacerbations. Cluster T2 was composed of nonsmokers with a mild-moderate airflow obstruction and no previous exacerbations. Validation clusters (V1, V2 and V3) were similar to the training set clusters. Differentially expressed proteins in sputum supernatants measured by liquid chromatography with tandem mass spectrometry pointed to differences in the complement and coagulation cascade pathway between Cluster 1 (T1 and V1) and Cluster 3 (T3 and V3), as well as between Cluster 2 (T2 and V2) and Cluster 3. Galectin 10 was upregulated in Cluster 1 compared with Cluster 2, and correlated with exacerbations, fractional exhaled nitric oxide, blood and sputum eosinophil count and oral corticosteroid dose in Cluster 1. Conclusion: The clinical clusters were differentiated by smoking status, degree of airflow obstruction and exacerbation history, and by sputum complement and coagulation pathways, and galectin 10 levels.

Identifiers

PMID40822235
PMCPMC12351390

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.