ArticleFrontiers in pharmacology2025
The pharmacokinetics effects of the MCAO model on senkyunolide I in pseudo germ-free rats after oral co-administration of Chuanxiong and warfarin.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
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- Integrated Computational Study Prioritizes Drug-like Para-Flavonoids as Candidate SARS-CoV-2 MCurrent issues in molecular biology · 2026Article
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- Novel 1,2,3-triazole-thiophene hybrids: synthesis, anti-MRSA/MSSA activity, antioxidant potential, and acetylcholinesterase ınhibition supported by molecular docking.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Therapeutic potential and synergistic effects of antifungal and off target drugs against clinical isolates of Cryptococcus laurentii.Scientific reports · 2026Article
- Redox-linked hormetic responses of Withania coagulans (Stocks) Dunal to Mn, Zn, and Fe supplementation in vitro.BMC plant biology · 2026Article
- Green analytical evaluation of anticancer drug analysis: A multi-tool assessment of HPLC and LC-MS methods.Scientific reports · 2026Article
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7 authors.
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Abstract
Aim: To investigate the pharmacokinetics effects of a middle cerebral artery occlusion (MCAO) model on senkyunolide I (SEI) in pseudo germ-free rats after oral co-administration of Chuanxiong and warfarin. Methods: Rats were divided randomly into WC_H, WS_H, WC_HF, WS_HF, WC, WS, WC_F, and WS_F groups (W, warfarin; C, Chuanxiong; S, SEI; H, rats without an MCAO operation; F, pseudo germ-free). Pseudo germ-free rats were orally administered ciprofloxacin hydrochloride (50 mg/kg, twice a day) for 3 consecutive days, and the MCAO operation was carried out on the third day. Chuanxiong (10 g/kg) or SEI (7.5 mg/kg) and warfarin sodium (0.5 mg/kg) were orally administered only once on the fourth day. The plasma concentrations of SEI were determined by UPLC-MS/MS. Stool samples were collected for gut microbiota analyses. The coronal thin slices of the brain were dyed with triphenyl-2H-tetrazolium chloride. Results: Compared to the WC_H group, the AUC Conclusion: Both the MCAO operation and the pseudo germ-free condition significantly changed the pharmacokinetics characteristics of SEI after oral co-administration with warfarin and Chuanxiong or SEI. It is a promising way to understand the potential pharmacokinetics of herb-drug interactions from the angle of the gut microbiota.
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