Evidence map›Paper›PMID 40822525›Full record

ArticleFood science & nutrition2025

Kombucha Prevents Indomethacin-Induced Enteric Damage in Wistar Rat by Enhancing Epithelial Gut Barrier and Modulating Gut Microbiota.

Atziri A Varela-Mendoza, Ma Magdalena Martínez-Flores, Melanie G Paz-Jiménez, Fernanda García-Acevedo, Laura E Córdova-Dávalos, Tonatiuh Barrios-García, Ma Consolación Martínez-Saldaña, Valeria Salinas-Guardado, Mariela Jiménez, Eva Salinas and 1 more

Abstract read
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Atziri A Varela-MendozaDepartment of Microbiology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.
Ma Magdalena Martínez-FloresDepartment of Microbiology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.
Melanie G Paz-JiménezDepartment of Microbiology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.
Fernanda García-AcevedoDepartment of Microbiology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.
Laura E Córdova-DávalosDepartment of Microbiology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.
Tonatiuh Barrios-GarcíaDepartment of Morphology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.
Ma Consolación Martínez-SaldañaDepartment of Morphology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.
Valeria Salinas-GuardadoDepartment of Microbiology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.
Mariela JiménezDepartment of Microbiology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.
Eva SalinasDepartment of Microbiology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.
Daniel Cervantes-GarcíaDepartment of Microbiology, Basic Science Center Autonomous University of Aguascalientes Aguascalientes Mexico.ORCID https://orcid.org/0000-0002-9711-8042

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kombucha is a fermented beverage with high contents of antioxidants and probiotics. Enteric damage due to uncontrolled consumption of non-steroidal anti-inflammatory drugs (NSAIDs) represents a significant cause of morbidity and mortality. This study aimed to evaluate the preventive effects of kombucha against indomethacin-induced enteric damage. Wistar rats were divided into control (Ctrl), supplemented with kombucha (Komb), indomethacin-induced enteric damage (Indo), and indomethacin-induced enteric damage and supplemented with kombucha (Indo-Komb) groups. We analyzed ulcer index, histological changes, gene expression of intestinal barrier function genes, and microbiota phyla in cecal content. Kombucha supplementation reduced ulcer index and intestinal inflammation, which improved survival (

Indexed as

gut inflammationkombuchamicrobiotaNSAIDspolyphenolstight junctions

Identifiers

PMID40822525
PMCPMC12357172

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.