Evidence map›Paper›PMID 40822578›Full record

SynthesisFrontiers in cellular and infection microbiology2025

Meta-analysis of

Xiongjian Wu, Haiyan Zhu, Ying Hu, Lei Zhang, Lixing Huang

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. BeyondMedicina (Kaunas, Lithuania) · 2025
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiongjian WuDepartment of Gastroenterology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Haiyan ZhuDepartment of Gastroenterology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Ying HuDepartment of Gastroenterology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Lei ZhangDepartment of Gastroenterology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Lixing HuangDepartment of Gastroenterology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: A meta-analysis was conducted using publicly available 16S rRNA and shotgun metagenomic datasets. Microbiome composition differences were assessed using differential abundance analysis, alpha- and beta-diversity metrics, and principal component analysis (PCA). Random forest models were employed to predict the clinical outcomes based on microbiome and clinical data. Hyperparameter tuning and cross-validation were applied to ensure model robustness. Results: The analysis revealed significant microbial shifts associated with Discussion: This study highlights the critical role of GM dysbiosis in

Indexed as

Gastrointestinal MicrobiomeHelicobacter InfectionsHelicobacter pyloriBacteriaDysbiosisGastritisHumansMetagenomicsRNA, Ribosomal, 16SStomach NeoplasmsRNA, Ribosomal, 16Sclinical applicationsgut microbiome (GM)H.pylorimeta-analysis (MA)predictive model (PM)

Identifiers

PMID40822578
PMCPMC12353726

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.