ArticleFrontiers in cellular and infection microbiology2025
Enhancing prognostic accuracy in sepsis: a modified SOFA score incorporating lymphocyte count as an immune function marker.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Immunoglobulin GFrontiers in immunology · 2026Article
- Failure of early lymphocyte recovery identifies sepsis patients with initial lymphopenia at highest risk for late mortality.PloS one · 2026Article
- An exploratory study evaluating the predictive capacity of the CALLY index and SOFA-2 for 28-day all-cause mortality in patients with septic shock.Frontiers in medicine · 2026Article
- Impact of absolute lymphocyte count upon admission to ICU on 28-day mortality in sepsis patients in ICU.Frontiers in immunology · 2025Article
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8 authors.
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Abstract
Background: Sepsis, characterized by organ dysfunction due to a dysregulated immune response, is diagnosed using the Sequential Organ Failure Assessment (SOFA) score, which currently lacks immune function markers. The objective of this research is to enhance the predictive precision of SOFA for sepsis by integrating lymphocyte count as an indicator of immune system functionality. Methods: This retrospective study was based on the MIMIC-IV database. The absolute lymphocyte count (ALC) was assessed as a predictive biomarker through multivariate analysis utilizing the Cox proportional-hazards model and was integrated into a modified SOFA score (ALC-SOFA). Associations between ALC-SOFA score and mortality were assessed using Kaplan-Meier survival analysis. Predictive performance was evaluated by comparing the area under the receiver operating characteristic (AUROC) curve for ALC-SOFA and the original SOFA score. The primary endpoint was the mortality rate at 28 days, with additional secondary endpoints including the mortality rates at 7 and 90 days. Results: 10,709 patients with sepsis were included in this study. ALC was significantly lower in nonsurvivors than in survivors (0.90 ± 0.62×10 Conclusion: Incorporating ALC into the SOFA score significantly improves its ability to predict sepsis-related outcomes. The ALC-SOFA score provides a novel tool for prognostic assessment, highlighting the critical role of immune function in sepsis management.
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