Evidence map›Paper›PMID 40822606›Full record

ArticleClinical case reports2025

A Case Report of Giant Congenital Melanocytic Nevus Complicated by Minimal Change Disease, With Genetic Analysis.

Geping Yu, Ting Hu, Ting Yu, Yihan Zhao, Xiao Xu

Abstract read
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Geping YuDepartment of Nephrology, Hangzhou First People's Hospital Tonglu Campus, School of Medicine Westlake University Hangzhou People's Republic of China.ORCID https://orcid.org/0009-0008-7322-0043
Ting HuDepartment of Nephrology, Hangzhou First People's Hospital Tonglu Campus, School of Medicine Westlake University Hangzhou People's Republic of China.
Ting YuDepartment of Nephrology, Hangzhou First People's Hospital Tonglu Campus, School of Medicine Westlake University Hangzhou People's Republic of China.
Yihan ZhaoDepartment of Nephrology, Hangzhou First People's Hospital Tonglu Campus, School of Medicine Westlake University Hangzhou People's Republic of China.
Xiao XuDepartment of Nephrology, Hangzhou First People's Hospital Tonglu Campus, School of Medicine Westlake University Hangzhou People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case describes a 39-year-old woman with congenital giant melanocytic nevus (GCMN) who developed new-onset nephrotic syndrome. Clinical evaluation revealed minimal change disease (MCD) confirmed by renal biopsy, with podocyte effacement on electron microscopy. Genetic testing identified four variants of uncertain significance, with no known pathogenic mutations. Treatment with corticosteroids, losartan, and low-molecular-weight heparin led to remission, and no relapse occurred after one year. The GCMN remained unchanged. This rare co-occurrence highlights the need to consider systemic associations in complex cases and suggests possible molecular links between dermatological and renal disorders requiring further investigation.

Indexed as

congenital giant congenital melanocytic nevusgeneticsminimal change diseasepodocyte injury

Identifiers

PMID40822606
PMCPMC12356702

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.