Evidence map›Paper›PMID 40822706›Full record

ArticleFrontiers in stroke2024

Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia.

Amelia M Burch, Ami Haas, James E Orfila, Erika Tiemeier, Cassidy De Anda Gamboa, Nicholas Chalmers, Nidia Quillinan, Paco S Herson

Abstract read
In one paragraph

Article in Frontiers in stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amelia M BurchDepartment of Anesthesiology, Neuronal Injury & Plasticity Program, University of Colorado School of Medicine, Aurora, CO, United States.
Ami HaasDepartment of Anesthesiology, Neuronal Injury & Plasticity Program, University of Colorado School of Medicine, Aurora, CO, United States.
James E OrfilaDepartment of Neurological Surgery, The Ohio State University College of Medicine, Columbus, OH, United States.
Erika TiemeierDepartment of Anesthesiology, Neuronal Injury & Plasticity Program, University of Colorado School of Medicine, Aurora, CO, United States.
Cassidy De Anda GamboaDepartment of Anesthesiology, Neuronal Injury & Plasticity Program, University of Colorado School of Medicine, Aurora, CO, United States.
Nicholas ChalmersDepartment of Anesthesiology, Neuronal Injury & Plasticity Program, University of Colorado School of Medicine, Aurora, CO, United States.
Nidia QuillinanDepartment of Anesthesiology, Neuronal Injury & Plasticity Program, University of Colorado School of Medicine, Aurora, CO, United States.
Paco S HersonDepartment of Neurological Surgery, The Ohio State University College of Medicine, Columbus, OH, United States.

Funding

Sex Steroids and Brain Outcome from Cardiac Arrest/Cardiopulmonary ResuscitationR01NS046072 · NINDS · UNIVERSITY OF COLORADO DENVER · PI HERSON, PACO S, QUILLINAN, NIDIA · 2002 to 2024
$7.0M
CaMKII in global cerebral ischemia: mechanisms and therapeutic interventionR01NS118786 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2021 to 2025
$1.9M
Targeting TRPM2 channels to improve synaptic and cognitive function after cerebral ischemiaR01NS092645 · NINDS · UNIVERSITY OF COLORADO DENVER · PI HERSON, PACO S · 2016 to 2020
$1.7M
New approach to sustained neuroprotection and enhanced recovery following acute ischemic strokeR01NS127413 · NINDS · OHIO STATE UNIVERSITY · PI Paco S Herson · 2025 to 2026
$1.1M
CD38 activation of TRPM2 in hippocampal neurons contributes to stroke-induced cognitive dysfunctionF31NS120422 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BURCH, AMELIA · 2021 to 2024
$124k
NINDS NIH HHS F31 NS120422NINDS NIH HHS R01 NS046072NINDS NIH HHS R01 NS092645NINDS NIH HHS R01 NS118786NINDS NIH HHS R01 NS127413
6 · The paper itself

Abstract

Cardiac arrest-induced global cerebral ischemia (GCI) results in profound cognitive impairment in survivors. Our prior work demonstrated persistent disruption of long-term potentiation (LTP) in hippocampal CA1 neurons, correlating with learning and memory deficits in a rodent model of cardiac arrest/cardiopulmonary resuscitation (CA/CPR). Delayed inhibition of the Ca

Indexed as

cardiac arrestCD38global cerebral ischemiahippocampusLTPTRPM2

Identifiers

PMID40822706
PMCPMC12356413

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.