Evidence map›Paper›PMID 40822845›Full record

ArticleBiochemia medica2025

Cystatin C for gentamicin dosing - a case study.

Tomáš Šálek, Josef Klhůfek, Martin Vodička, Marek Pšenčík

Abstract readCase Reports
In one paragraph

Article in Biochemia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tomáš ŠálekDepartment of Clinical Biochemistry and Pharmacology, Tomas Bata Hospital in Zlín, Zlín, Czech Republic.
Josef KlhůfekDepartment of Clinical Pharmacy, Tomas Bata Hospital in Zlín, Zlín, Czech Republic.
Martin VodičkaDepartment of Clinical Pharmacy, Tomas Bata Hospital in Zlín, Zlín, Czech Republic.
Marek PšenčíkDepartment of Clinical Biochemistry and Pharmacology, Tomas Bata Hospital in Zlín, Zlín, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aims to present a case study of a patient with supratherapeutic serum gentamicin concentration. An 83-year-old male was admitted to the Department of Internal Medicine for persistent loss of appetite, decompensated heart failure, and pneumonia. He was treated with 240 mg gentamicin daily alongside ampicillin/sulbactam penicillin antibiotic. The trough gentamicin concentrations and estimated glomerular filtration rate from creatinine (eGFRcrea) and cystatin C (eGFRcys) were performed. The patient had the supratherapeutic trough gentamicin concentration of 2.5 mg/L. eGFRcrea was 62 mL/min/1.73m

Indexed as

Anti-Bacterial AgentsCystatin CGentamicinsAged, 80 and overCreatinineGlomerular Filtration RateHumansMalePneumoniaAnti-Bacterial AgentsCreatinineCystatin CGentamicinscreatininecystatin Cdrug overdosegentamicinsglomerular filtration rate

Identifiers

PMID40822845
PMCPMC12334943

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.