Evidence map›Paper›PMID 40822934›Full record

ArticleMaterials today. Bio2025

A sprayable exosome-loaded hydrogel with controlled release and multifunctional synergistic effects for diabetic wound healing.

Bo Liu, Lianglong Chen, Chaoyang Huang, HuiHui Zhang, Hai Zhou, Yanqi Chen, Xiaoyang Liu, Zhenyong Xiao, Kangyan Liang, Xiangtao Xie and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bo LiuDepartment of Plastic and Aesthetic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Lianglong ChenDepartment of Burns, Nanfang Hospital, Southern Medical University, Jingxi Street, Baiyun District, Guangdong, 510515, China.
Chaoyang HuangDepartment of Burns, Nanfang Hospital, Southern Medical University, Jingxi Street, Baiyun District, Guangdong, 510515, China.
HuiHui ZhangDepartment of Burns, Nanfang Hospital, Southern Medical University, Jingxi Street, Baiyun District, Guangdong, 510515, China.
Hai ZhouDepartment of Burns, Nanfang Hospital, Southern Medical University, Jingxi Street, Baiyun District, Guangdong, 510515, China.
Yanqi ChenDepartment of Burns, Nanfang Hospital, Southern Medical University, Jingxi Street, Baiyun District, Guangdong, 510515, China.
Xiaoyang LiuDepartment of Burns, Nanfang Hospital, Southern Medical University, Jingxi Street, Baiyun District, Guangdong, 510515, China.
Zhenyong XiaoGuangxi Key Laboratory of Orthopedic Biomaterials Development and Clinical Translation, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, 545005, China.
Kangyan LiangGuangdong Qianhui Biotechnology Co., Ltd., Guangzhou, 510285, China.
Xiangtao XieGuangxi Key Laboratory of Orthopedic Biomaterials Development and Clinical Translation, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, 545005, China.
Yi GaoDepartment of Hepatobiliary Surgery II, Guangdong Engineering Technology Research Center of Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Kun LiuExperimental Education/Administration Center, National Demonstration Center for Experimental Education of Basic Medical Sciences, Key Laboratory of Functional Proteomics of Guangdong Province, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Xiangdong QiDepartment of Plastic and Aesthetic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wound healing is hindered by bacterial infections, oxidative stress, impaired vascularization, and chronic inflammation. Conventional dressings, limited by static drug release and single-functionality, fail to dynamically match the varying demands of different healing stages and dressing replacement frequencies. This study developed a multifunctional sprayable hydrogel dressing (Exo@AMCN) by photocrosslinking methacrylated decellularized dermal matrix co-loaded with human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exo) and β-cyclodextrin-borneol inclusion complexes (CN). The hydrogel can be sprayed onto irregularly shaped wounds, with its crosslinking density and degradation kinetics precisely modulated by adjusting the photocuring duration. This tunability enables controlled release of exosomes and borneol over 2-7 days. Experimental findings demonstrate that Exo@AMCN displays excellent biocompatibility, broad-spectrum antibacterial activity (>85 % efficacy), and robust reactive oxygen species scavenging capacity. The dressing significantly boosts cell migration, fosters angiogenesis, and prompts macrophage polarization toward anti-inflammatory phenotypes. In a diabetic wound model, Exo@AMCN reduced residual wound area to 1.07 ± 1.27 % within 14 days by modulating tissue inflammation, enhancing collagen deposition, and stimulating neovascularization. This innovative approach, combining controlled drug release with multifunctional synergy, offers a promising individualized solution for managing diabetic wounds.

Indexed as

Acellular dermal matrixBorneolDiabetic wound healingExosomesHydrogel

Identifiers

PMID40822934
PMCPMC12355498

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.