Evidence mapPaperPMID 40822955Full record

ArticleFrontiers in endocrinology2025

Agian Jeffilano Barinda, Wawaimuli Arozal, Nounik Cheri Dwita, Muhamad Sadam Safutra, Ippei Shimizu, Yung Ting Hsiao, Normalina Sandora, Rani Wardani Hakim, Nurul Gusti Khatimah, Harri Hardi

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Agian Jeffilano BarindaDepartment of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Wawaimuli ArozalDepartment of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Nounik Cheri DwitaMaster Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Muhamad Sadam SafutraMaster Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Ippei ShimizuDepartment of Cardiovascular Aging, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
Yung Ting HsiaoDepartment of Cardiovascular Aging, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
Normalina SandoraInstitute of Medical Education and Research Indonesia, Jakarta, Indonesia.
Rani Wardani HakimDepartment of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Nurul Gusti KhatimahDoctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Harri HardiClinical Pharmacology Specialist Study Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin Resistance (IR) is a complication that frequently occurs in obesity. The inflammation-mediated senescence in White Adipose Tissue (WAT) is important in obesity-induced IR. Centella asiatica (CA) is a potential medicinal plant with anti-aging and anti-obesity properties. Here, we explored the effect of CA on obesity-mediated IR in mice fed with a High Fat-High Fructose (HFHF) diet and treated simultaneously with CA at 150 mg/kgBW (CA150) or 300 mg/kgBW (CA300). The total body mass and visceral WAT weight in both CA groups decreased in comparison with HFHF group alone. We demonstrated that HFHF-diet mice treated with CA300 improved insulin sensitivity and enhanced

Indexed as

Adipose TissueAdipose Tissue, WhiteAgingCellular SenescenceInflammationInsulin ResistanceMacrophagesObesityPlant ExtractsTriterpenesAnimalsCentellaDiet, High-FatMaleMiceMice, Inbred C57BLCentella asiatica extractPlant ExtractsTriterpenesCentella asiaticainflammationinsulin resistanceM1 pro-inflammatory macrophageobesitysenescencewhite adipose tissue

Identifiers

PMID40822955
PMCPMC12350134

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.