SynthesisFrontiers in public health2025
The impact of depression on mortality among older adult patients with hypertension: a systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk and protective factors associated with depressive symptoms in older adults with visual impairment: a systematic review.The Gerontologist · 2026Pooled it
- Article
- Editorial: Hypertension and cardiorenal syndrome and their relationship with aging: friends and foes.Frontiers in aging · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Depression and hypertension frequently coexist in the older adult and may jointly contribute to increased mortality and cardiovascular risk. However, the extent to which depression independently affects these outcomes remains unclear. This systematic review and meta-analysis aimed to evaluate the association between depression and all-cause mortality in older adult patients with hypertension. Methods: We systematically searched PubMed, Embase, Cochrane Library, and Web of Science (2010-2024) for relevant cohort studies and randomized controlled trials. Pooled hazard ratios (HRs) were calculated using a random-effects model. Subgroup and sensitivity analyses were performed. The study protocol was registered in PROSPERO (CRD420251019904). Results: Thirteen studies including 483,560 participants showed that depression was associated with increased all-cause mortality (HR = 1.32, 95% CI: 1.23-1.41). The association was stronger among females (HR = 1.57) and in studies with short-term follow-up (<10 years, HR = 1.40). The findings were consistent across different depression assessment tools. Conclusion: Depression is independently associated with higher all-cause mortality in older adult hypertensive patients. Routine screening and management of depression-particularly among older women-may improve long-term outcomes. Further interventional studies are needed to evaluate the prognostic impact of depression treatment in this population. Systematic review registration: The systematic review was registered with PROSPERO (CRD420251019904).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.