ArticleLancet regional health. Americas2025
The potential for dementia prevention in Brazil: a population attributable fraction calculation for 14 modifiable risk factors.
Article in Lancet regional health. Americas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Cognitive trajectories and mortality risk in older adults: a 9-year follow-up study.GeroScience · 2026Article
- Implementation of stroke prevention: a review of challenges and opportunities in the Americas.Lancet regional health. Americas · 2026Review
- Differences in the prevalence and patterns of dementia risk factors across 14 countries and regions: a harmonised cross-national analysis.The lancet. Healthy longevity · 2026Article
- Cross-sectional and longitudinal cognitive trajectories associated with dementia comorbidity clusters: Results from a 10-year follow-up real-world outpatient memory clinic in Brazil.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The incidence of dementia in populations around the globe.Current opinion in psychiatry · 2026Review
- Dementia and cognitive decline in Black Brazilians: a narrative review.Frontiers in human neuroscience · 2026Review
- The potential for dementia prevention in Japan: a population attributable fraction calculation for 14 modifiable risk factors and estimates of the impact of risk factor reductions.The Lancet regional health. Western Pacific · 2026Article
- The clock drawing test as a screening tool for detecting cognitive decline: an analysis in adults and elderly people from Natal (RN).Frontiers in human neuroscience · 2026Article
- Construction of a classification model for dementia among Brazilian adults aged 50 and over.Frontiers in aging neuroscience · 2026Article
- Apolipoprotein E and Alzheimer's disease pathology in a diverse autopsy study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Stratifying dementia risk factors: A prediction model and hypothesis-driven analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Complementary approaches to improve cognitive health through prevention in Brazil.Lancet regional health. Americas · 2025Article
- Accuracy of the revised Addenbrooke Cognitive Examination (ACE-R) and Mini-Mental (MMSE) in a Quilombola community with low education attainment: results of a cross-sectional study.Frontiers in dementia · 2025Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The Lancet Commission on dementia prevention, intervention, and care 2024 updated the list of modifiable risk factors to include 14 factors. The potential for dementia prevention seems to be greater in low- and middle-income countries (LMIC) due to the higher prevalence of these factors. This study aims to provide the first LMIC figure for the potential for dementia prevention in Brazil attributed to 14 modifiable risk factors. Methods: Data was retrieved from 9949 participants aged 50 years or older from the nationally representative second wave of the Brazilian Longitudinal Study of Aging (ELSI-Brazil) conducted between 2019 and 2021. The prevalence of modifiable risk factors was estimated, and principal component analysis was used to account for factor communalities. Overall and individual population attributable fractions (PAF) were calculated using relative risks from the 2024 Lancet Commission report. Stratified analyses by sex, race, and Brazilian macro regions were performed to assess disparities in dementia risk. Findings: The overall PAF for the 14 modifiable risk factors was 59.5% (95% CI = 58.5-60.5). The three risk factors with the highest PAFs were less education (9.5%, 95% CI = 8.9-10.1), untreated visual loss (9.2%, 95% CI = 8.6-9.8), and midlife depression (6.3%, 95% CI = 5.8-6.8). The overall PAF was similar across race and region but was higher among women (61.1%, 95% CI = 59.9-62.4) compared to men (58.2%, 95% CI = 56.7-59.8). Interpretation: Almost 60% of dementia cases in Brazil could potentially be prevented by addressing 14 modifiable risk factors. Public health strategies could further reduce the dementia burden in Brazil. Funding: CKS, PC, and CPF received productivity fellowships from the National Council for Scientific and Technological Development (CNPq). ELSI-Brazil was supported by the Brazilian Ministry of Health: DECIT/SCTIE (Grants: 404965/2012-1 and TED 28/2017); COPID/DECIV/SAPS (Grants: 20836, 22566, 23700, 25560, 25552, and 27510).
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