Evidence map›Paper›PMID 40823340›Full record

ArticleNature. Mental health2025

Proteogenomic signature of Alzheimer's disease and related dementia risk in individuals with major depressive disorder.

Breno Satler Diniz, Zhiduo Chen, David C Steffens, Luke Pilling, Yuliya Nikolova, Kevan Clifford, Richard H Fortinsky, George A Kuchel, Chia-Ling Kuo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature. Mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Proteogenomics in human populations.Nature reviews. Genetics · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Breno Satler DinizUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
Zhiduo ChenUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
David C SteffensDepartment of Psychiatry, University of Connecticut Health Center, Farmington, CT, USA.
Luke PillingEpidemiology and Public Health Group, Department of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Yuliya NikolovaThe Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut, USA.
Kevan CliffordCentre for Addiction and Mental Health, Toronto, Canada.
Richard H FortinskyUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
George A KuchelUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
Chia-Ling KuoUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.

Funding

Research Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5M
THE SENDEP STUDY: LINKING MOLECULAR SENESCENCE CHANGES TO DEPRESSION AND COGNITIVE IMPAIRMENT IN LATE LIFER01MH115953 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DINIZ, BRENO SATLER · 2019 to 2023
$3.0M
NIA NIH HHS P30 AG067988NIMH NIH HHS R01 MH115953
6 · The paper itself

Abstract

The mechanisms linking a history of major depressive disorder (MDD) to an increased risk of Alzheimer's disease and related dementia (ADRD) are not fully understood. Using the UK Biobank, we evaluated the biological mechanisms linking both conditions. In participants without history of MDD, 493 proteins were significantly associated with the risk of ADRD. In contrast, in participants with a history of MDD at baseline, a smaller set of 6 proteins were significantly associated ADRD risk (NfL, GFAP, PSG1. VGF, GET3, and HPGDS), with GET3 being specifically associated with ADRD risk in the latter group. Two-sample Mendelian randomization analysis ahowed that the APOE and IL-10 receptor subunit B genes were causally linked to incident ADRD. Finally, we developed a Proteomic Risk Score (PrRS

Indexed as

Alzheimer's diseasedementiagenomicsinflammationMajor depressive disorderproteomics

Identifiers

PMID40823340
PMCPMC12356225

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.