Evidence map›Paper›PMID 40823709›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration.

Xiaoling Deng, Yu Zhuang, Jinjie Cui, Liyun Wang, Huilu Zhan, Xudong Wang, Kaili Lin, Changyong Yuan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. A Piezo-Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  9. Article
  10. Review
  11. Article
  12. Review
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  15. Review
  16. Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoling DengDepartment of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yu ZhuangDepartment of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Jinjie CuiDepartment of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Liyun WangDepartment of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Huilu ZhanDepartment of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Xudong WangDepartment of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Kaili LinDepartment of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.ORCID https://orcid.org/0000-0002-1900-9641
Changyong YuanSchool of Stomatology, Xuzhou Medical University, Affiliated Stomatological Hospital of Xuzhou Medical University, Xuzhou, 221004, China.

Funding

CAMS Innovation Fund for Medical Sciences 2019-I2M-5-037National Natural Science Foundation of China 32271379Research Project of Xuzhou Municipal Health Commission XWKYHT20230077Science and Technology Commission of Shanghai Municipality 23YF1421500Science and Technology Commission of Shanghai Municipality 24YF2723100Shanghai's Top Priority Research Center 2022ZZ01017
6 · The paper itself

Abstract

Emerging piezoelectric biomaterials have demonstrated their huge potential in diverse medical applications, including ultrasound diagnosis and tissue regeneration. Human body possesses inherent piezoelectricity, producing electrical signal under endogenous load or external pressure to modulate cellular behaviors. Tissue defects caused by traumatic injury will disrupt the electrophysiological microenvironment of the injured area, resulting in unenviable self-healing. Triggered by physical activities or external stimulation, piezoelectric biomaterials exhibit a unique capability to generate electrical fields to restore the electrophysical microenvironment, reprogram cell fate and ultimately facilitate tissue repair. In this review, endogenous piezoelectric substances in the body and tissue piezoelectricity are introduced. Then, the characteristics and piezoelectricity of piezoelectric biomaterials in regenerative medicine are discussed, as well as strategies to prepare novel piezoelectric composites. Moreover, the molecular mechanisms for the piezoelectric effect on regulating tissue regeneration are systematically summarized. Recent advancements in piezoelectric biomaterials are comprehensively overviewed, including in the regeneration of bone, cartilage, skeletal muscles, tendon, skin, nerve, teeth and periodontal, myocardium, blood vessel and cornea tissues. Finally, the major challenges and future perspectives of piezoelectric biomaterials in regenerative medicine are proposed, hoping to boost the advancement in this promising scientific territory.

Indexed as

Biocompatible MaterialsRegenerationRegenerative MedicineTissue EngineeringAnimalsHumansBiocompatible Materialsbiomaterialselectrical stimulationpiezoelectric effecttissue regeneration

Identifiers

PMID40823709
PMCPMC12520560

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.