ArticlemBio2025
Fungal-fungal cocultivation alters secondary metabolites of marine fungi mediated by reactive oxygen species (ROS).
Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Genome mining of Trp-anthranilic acid cyclic dipeptides in Aspergillus driven by analysis of NRPS adenylation domains.Archives of microbiology · 2026Article
- Potential of Indonesian Marine Endophytic Fungi as Extracellular Enzymes Producers.Journal of fungi (Basel, Switzerland) · 2026Article
- From Contact to Stalemate: MAPK-Associated Chemical and Enzymatic Defenses Shape a Stable Barrage in the Co-Culture ofJournal of fungi (Basel, Switzerland) · 2026Article
- Fungal-fungal interaction between Sanghuangporus vaninii and its endophytic Fusarium solani rewires host secondary metabolism to boost bioactive metabolite production.Microbial cell factories · 2026Article
- Gold nanoparticle-mediated metabolic engineering in Trichoderma longibrachiatum MD33 unveils a hybrid terpenoid-alkaloid pathway for enhanced dendrobine biosynthesis.Microbial cell factories · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Microorganisms form complex ecological networks of interactions, with secondary metabolites (SMs) playing a crucial role in microbial communication. This study explored the cocultivation of marine fungi IMPORTANCE: Marine fungi are an important source of natural products, and many marine-derived secondary metabolites have been found to exhibit significant bioactivities, including antibacterial, antiviral, and anticancer properties. Cocultivation is a simple and effective method for discovering bioactive compounds. However, whether marine-derived and terrestrial-derived microorganisms exhibit differential response mechanisms under co-culture conditions remains unexplored. Our study details how cocultivation of marine fungi triggers the activation of biosynthetic gene clusters (BGCs) and leads to an increase in active secondary metabolites (SMs), which may contribute to the future development of antibiotics or anticancer drugs. Furthermore, our findings reveal that reactive oxygen species (ROS) function as specific signaling molecules in marine fungal-fungal interactions, offering novel insights into the evolutionary strategies of fungi in marine ecosystems.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.