Evidence mapPaperPMID 40823949Full record

ArticleJournal of research in health sciences2025

Food Insecurity Is an Important Risk Factor for Alzheimer's Disease: A Case-Control Study.

Mohammad Mehdi Abbasi, Mahdyeh Karimi, Sajjad Khandae, Bahram Rashidkhani

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Article in Journal of research in health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Mohammad Mehdi AbbasiDepartment and Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-3179-9527
Mahdyeh KarimiDepartment and Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sajjad KhandaeDepartment and Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bahram RashidkhaniDepartment of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-1822-8711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a gap in the literature specifically addressing the relationship between food insecurity and the risk of Alzheimer's disease (AD).

methodsThis study aimed to evaluate the association between food insecurity and the risk of AD in 301 participants, including 150 cases and 151 controls. Cases were recruited among people in the early stages of the disease who had been diagnosed with AD within the past six months. Controls were selected from health centers across Tehran. Food security status was assessed using the validated Persian translation of the 18-item United States Department of Agriculture's household food security questionnaire.

resultsAfter adjusting for potential cofounders, food insecurity was associated with a higher risk of AD (odds ratio [OR]: 2.80; 95% confidence interval [CI]: 1.59-4.94). Among female participants, food insecurity increased the odds of AD (OR: 3.54; 95% CI: 1.72-7.30). For individuals under 65, food insecurity also increased the likelihood of AD nearly four-fold (OR: 3.94, 95% CI: 1.48-10.47), while for those over 65, the risk was only 2.89 times (OR: 2.89, 95% CI: 1.36-6.14).

conclusionFood insecurity might be associated with an increased risk of AD. Further research is required to explore the relationship between food insecurity and other types of neurological disorders or health conditions. More precisely, future studies should aim to investigate the association in a prospective design.

Indexed as

Alzheimer DiseaseFood InsecurityFood SupplyAgedAged, 80 and overCase-Control StudiesFemaleHumansIranMaleMiddle AgedOdds RatioRisk FactorsSex FactorsSurveys and QuestionnairesAlzheimer’s diseaseDementiaDietFood insecurityNeurocognitive disorders

Identifiers

PMID40823949
PMCPMC12445880

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.